Novel delivery approaches for cancer therapeutics
Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often...
Gespeichert in:
| Veröffentlicht in: | Journal of controlled release 2015-12, Vol.219, p.248-268 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 268 |
|---|---|
| container_issue | |
| container_start_page | 248 |
| container_title | Journal of controlled release |
| container_volume | 219 |
| creator | Mitra, Ashim K. Agrahari, Vibhuti Mandal, Abhirup Cholkar, Kishore Natarajan, Chandramouli Shah, Sujay Joseph, Mary Trinh, Hoang M. Vaishya, Ravi Yang, Xiaoyan Hao, Yi Khurana, Varun Pal, Dhananjay |
| description | Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It is widely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, these treatment modalities are associated with severe side effects and high toxicity which in turn lead to low quality of life. This review encompasses novel strategies for more effective chemotherapeutic delivery aiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significant advances are being made in the development of novel cancer treatment strategies. In contrast to conventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggered release, intracellular drug targeting, gene delivery, cancer stem cell therapy, magnetic drug targeting and ultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approaches have led to selective detection of malignant cells leading to their eradication with minimal side effects. Lowering multi-drug resistance and involving influx transportation in targeted drug delivery to cancer cells can also contribute significantly in the therapeutic interventions in cancer.
[Display omitted] |
| doi_str_mv | 10.1016/j.jconrel.2015.09.067 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4656058</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S016836591530167X</els_id><sourcerecordid>2000389006</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-e3822d61ee34e43d1ba70903cd5e5280c4da699335afcaa67b9b1083c390de9f3</originalsourceid><addsrcrecordid>eNqFkMtOwzAQRS0EgvL4BFCWbBLGcezEGxCqeEkINrC2XHtCXaVxsNNK_D1GLQhWrGYx594ZHUJOKRQUqLhYFAvj-4BdUQLlBcgCRL1DJrSpWV5JyXfJJHFNzgSXB-QwxgUAcFbV--SgFBUXNYcJoU9-jV1msXNrDB-ZHobgtZljzFofMqN7gyEb5xj0gKvRmXhM9lrdRTzZziPyenvzMr3PH5_vHqbXj7nhrB5zZE1ZWkERWYUVs3Sma5DAjOXIywZMZbWQkjGuW6O1qGdyRqFhhkmwKFt2RC43vcNqtkRrsB-D7tQQ3FKHD-W1U383vZurN79WleACeJMKzrcFwb-vMI5q6aLBrtM9-lVUZfLBGgkgEso3qAk-xoDtzxkK6ku3WqitbvWlW4FUSXfKnf3-8Sf17TcBVxsAk6m1w6CicZicWhfQjMp698-JT2RHlQE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2000389006</pqid></control><display><type>article</type><title>Novel delivery approaches for cancer therapeutics</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mitra, Ashim K. ; Agrahari, Vibhuti ; Mandal, Abhirup ; Cholkar, Kishore ; Natarajan, Chandramouli ; Shah, Sujay ; Joseph, Mary ; Trinh, Hoang M. ; Vaishya, Ravi ; Yang, Xiaoyan ; Hao, Yi ; Khurana, Varun ; Pal, Dhananjay</creator><creatorcontrib>Mitra, Ashim K. ; Agrahari, Vibhuti ; Mandal, Abhirup ; Cholkar, Kishore ; Natarajan, Chandramouli ; Shah, Sujay ; Joseph, Mary ; Trinh, Hoang M. ; Vaishya, Ravi ; Yang, Xiaoyan ; Hao, Yi ; Khurana, Varun ; Pal, Dhananjay</creatorcontrib><description>Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It is widely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, these treatment modalities are associated with severe side effects and high toxicity which in turn lead to low quality of life. This review encompasses novel strategies for more effective chemotherapeutic delivery aiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significant advances are being made in the development of novel cancer treatment strategies. In contrast to conventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggered release, intracellular drug targeting, gene delivery, cancer stem cell therapy, magnetic drug targeting and ultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approaches have led to selective detection of malignant cells leading to their eradication with minimal side effects. Lowering multi-drug resistance and involving influx transportation in targeted drug delivery to cancer cells can also contribute significantly in the therapeutic interventions in cancer.
[Display omitted]</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2015.09.067</identifier><identifier>PMID: 26456750</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>adverse effects ; Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - therapeutic use ; Cancer ; Cell Penetrating Peptides ; Chemotherapeutics ; Drug Delivery Systems ; Drug Resistance, Neoplasm ; drug therapy ; drugs ; Efflux Pumps ; Gene therapy ; gene transfer ; Humans ; Immunotherapy ; ligands ; Molecular Targeted Therapy ; multiple drug resistance ; Nanoparticles - administration & dosage ; Nanoparticles - therapeutic use ; neoplasm cells ; neoplasms ; Neoplasms - drug therapy ; Neoplasms - therapy ; Prodrugs - therapeutic use ; prognosis ; quality of life ; radiotherapy ; Stem cells ; surgery ; Targeted Drug Delivery ; toxicity ; transportation ; Tumor</subject><ispartof>Journal of controlled release, 2015-12, Vol.219, p.248-268</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-e3822d61ee34e43d1ba70903cd5e5280c4da699335afcaa67b9b1083c390de9f3</citedby><cites>FETCH-LOGICAL-c537t-e3822d61ee34e43d1ba70903cd5e5280c4da699335afcaa67b9b1083c390de9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016836591530167X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26456750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitra, Ashim K.</creatorcontrib><creatorcontrib>Agrahari, Vibhuti</creatorcontrib><creatorcontrib>Mandal, Abhirup</creatorcontrib><creatorcontrib>Cholkar, Kishore</creatorcontrib><creatorcontrib>Natarajan, Chandramouli</creatorcontrib><creatorcontrib>Shah, Sujay</creatorcontrib><creatorcontrib>Joseph, Mary</creatorcontrib><creatorcontrib>Trinh, Hoang M.</creatorcontrib><creatorcontrib>Vaishya, Ravi</creatorcontrib><creatorcontrib>Yang, Xiaoyan</creatorcontrib><creatorcontrib>Hao, Yi</creatorcontrib><creatorcontrib>Khurana, Varun</creatorcontrib><creatorcontrib>Pal, Dhananjay</creatorcontrib><title>Novel delivery approaches for cancer therapeutics</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It is widely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, these treatment modalities are associated with severe side effects and high toxicity which in turn lead to low quality of life. This review encompasses novel strategies for more effective chemotherapeutic delivery aiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significant advances are being made in the development of novel cancer treatment strategies. In contrast to conventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggered release, intracellular drug targeting, gene delivery, cancer stem cell therapy, magnetic drug targeting and ultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approaches have led to selective detection of malignant cells leading to their eradication with minimal side effects. Lowering multi-drug resistance and involving influx transportation in targeted drug delivery to cancer cells can also contribute significantly in the therapeutic interventions in cancer.
[Display omitted]</description><subject>adverse effects</subject><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cancer</subject><subject>Cell Penetrating Peptides</subject><subject>Chemotherapeutics</subject><subject>Drug Delivery Systems</subject><subject>Drug Resistance, Neoplasm</subject><subject>drug therapy</subject><subject>drugs</subject><subject>Efflux Pumps</subject><subject>Gene therapy</subject><subject>gene transfer</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>ligands</subject><subject>Molecular Targeted Therapy</subject><subject>multiple drug resistance</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - therapeutic use</subject><subject>neoplasm cells</subject><subject>neoplasms</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - therapy</subject><subject>Prodrugs - therapeutic use</subject><subject>prognosis</subject><subject>quality of life</subject><subject>radiotherapy</subject><subject>Stem cells</subject><subject>surgery</subject><subject>Targeted Drug Delivery</subject><subject>toxicity</subject><subject>transportation</subject><subject>Tumor</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EgvL4BFCWbBLGcezEGxCqeEkINrC2XHtCXaVxsNNK_D1GLQhWrGYx594ZHUJOKRQUqLhYFAvj-4BdUQLlBcgCRL1DJrSpWV5JyXfJJHFNzgSXB-QwxgUAcFbV--SgFBUXNYcJoU9-jV1msXNrDB-ZHobgtZljzFofMqN7gyEb5xj0gKvRmXhM9lrdRTzZziPyenvzMr3PH5_vHqbXj7nhrB5zZE1ZWkERWYUVs3Sma5DAjOXIywZMZbWQkjGuW6O1qGdyRqFhhkmwKFt2RC43vcNqtkRrsB-D7tQQ3FKHD-W1U383vZurN79WleACeJMKzrcFwb-vMI5q6aLBrtM9-lVUZfLBGgkgEso3qAk-xoDtzxkK6ku3WqitbvWlW4FUSXfKnf3-8Sf17TcBVxsAk6m1w6CicZicWhfQjMp698-JT2RHlQE</recordid><startdate>20151210</startdate><enddate>20151210</enddate><creator>Mitra, Ashim K.</creator><creator>Agrahari, Vibhuti</creator><creator>Mandal, Abhirup</creator><creator>Cholkar, Kishore</creator><creator>Natarajan, Chandramouli</creator><creator>Shah, Sujay</creator><creator>Joseph, Mary</creator><creator>Trinh, Hoang M.</creator><creator>Vaishya, Ravi</creator><creator>Yang, Xiaoyan</creator><creator>Hao, Yi</creator><creator>Khurana, Varun</creator><creator>Pal, Dhananjay</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20151210</creationdate><title>Novel delivery approaches for cancer therapeutics</title><author>Mitra, Ashim K. ; Agrahari, Vibhuti ; Mandal, Abhirup ; Cholkar, Kishore ; Natarajan, Chandramouli ; Shah, Sujay ; Joseph, Mary ; Trinh, Hoang M. ; Vaishya, Ravi ; Yang, Xiaoyan ; Hao, Yi ; Khurana, Varun ; Pal, Dhananjay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-e3822d61ee34e43d1ba70903cd5e5280c4da699335afcaa67b9b1083c390de9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>adverse effects</topic><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Cancer</topic><topic>Cell Penetrating Peptides</topic><topic>Chemotherapeutics</topic><topic>Drug Delivery Systems</topic><topic>Drug Resistance, Neoplasm</topic><topic>drug therapy</topic><topic>drugs</topic><topic>Efflux Pumps</topic><topic>Gene therapy</topic><topic>gene transfer</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>ligands</topic><topic>Molecular Targeted Therapy</topic><topic>multiple drug resistance</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - therapeutic use</topic><topic>neoplasm cells</topic><topic>neoplasms</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - therapy</topic><topic>Prodrugs - therapeutic use</topic><topic>prognosis</topic><topic>quality of life</topic><topic>radiotherapy</topic><topic>Stem cells</topic><topic>surgery</topic><topic>Targeted Drug Delivery</topic><topic>toxicity</topic><topic>transportation</topic><topic>Tumor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitra, Ashim K.</creatorcontrib><creatorcontrib>Agrahari, Vibhuti</creatorcontrib><creatorcontrib>Mandal, Abhirup</creatorcontrib><creatorcontrib>Cholkar, Kishore</creatorcontrib><creatorcontrib>Natarajan, Chandramouli</creatorcontrib><creatorcontrib>Shah, Sujay</creatorcontrib><creatorcontrib>Joseph, Mary</creatorcontrib><creatorcontrib>Trinh, Hoang M.</creatorcontrib><creatorcontrib>Vaishya, Ravi</creatorcontrib><creatorcontrib>Yang, Xiaoyan</creatorcontrib><creatorcontrib>Hao, Yi</creatorcontrib><creatorcontrib>Khurana, Varun</creatorcontrib><creatorcontrib>Pal, Dhananjay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitra, Ashim K.</au><au>Agrahari, Vibhuti</au><au>Mandal, Abhirup</au><au>Cholkar, Kishore</au><au>Natarajan, Chandramouli</au><au>Shah, Sujay</au><au>Joseph, Mary</au><au>Trinh, Hoang M.</au><au>Vaishya, Ravi</au><au>Yang, Xiaoyan</au><au>Hao, Yi</au><au>Khurana, Varun</au><au>Pal, Dhananjay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel delivery approaches for cancer therapeutics</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2015-12-10</date><risdate>2015</risdate><volume>219</volume><spage>248</spage><epage>268</epage><pages>248-268</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><abstract>Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It is widely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, these treatment modalities are associated with severe side effects and high toxicity which in turn lead to low quality of life. This review encompasses novel strategies for more effective chemotherapeutic delivery aiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significant advances are being made in the development of novel cancer treatment strategies. In contrast to conventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggered release, intracellular drug targeting, gene delivery, cancer stem cell therapy, magnetic drug targeting and ultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approaches have led to selective detection of malignant cells leading to their eradication with minimal side effects. Lowering multi-drug resistance and involving influx transportation in targeted drug delivery to cancer cells can also contribute significantly in the therapeutic interventions in cancer.
[Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26456750</pmid><doi>10.1016/j.jconrel.2015.09.067</doi><tpages>21</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2015-12, Vol.219, p.248-268 |
| issn | 0168-3659 1873-4995 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4656058 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | adverse effects Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Cancer Cell Penetrating Peptides Chemotherapeutics Drug Delivery Systems Drug Resistance, Neoplasm drug therapy drugs Efflux Pumps Gene therapy gene transfer Humans Immunotherapy ligands Molecular Targeted Therapy multiple drug resistance Nanoparticles - administration & dosage Nanoparticles - therapeutic use neoplasm cells neoplasms Neoplasms - drug therapy Neoplasms - therapy Prodrugs - therapeutic use prognosis quality of life radiotherapy Stem cells surgery Targeted Drug Delivery toxicity transportation Tumor |
| title | Novel delivery approaches for cancer therapeutics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T11%3A26%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Novel%20delivery%20approaches%20for%20cancer%20therapeutics&rft.jtitle=Journal%20of%20controlled%20release&rft.au=Mitra,%20Ashim%20K.&rft.date=2015-12-10&rft.volume=219&rft.spage=248&rft.epage=268&rft.pages=248-268&rft.issn=0168-3659&rft.eissn=1873-4995&rft_id=info:doi/10.1016/j.jconrel.2015.09.067&rft_dat=%3Cproquest_pubme%3E2000389006%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2000389006&rft_id=info:pmid/26456750&rft_els_id=S016836591530167X&rfr_iscdi=true |