Nano-enabled delivery of diverse payloads across complex biological barriers
Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocar...
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| Veröffentlicht in: | Journal of controlled release 2015-12, Vol.219, p.548-559 |
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| container_title | Journal of controlled release |
| container_volume | 219 |
| creator | Ross, Kathleen A. Brenza, Timothy M. Binnebose, Andrea M. Phanse, Yashdeep Kanthasamy, Anumantha G. Gendelman, Howard E. Salem, Aliasger K. Bartholomay, Lyric C. Bellaire, Bryan H. Narasimhan, Balaji |
| description | Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases.
Nanocarriers functionalized with active and passive targeting strategies enable the efficient delivery of diverse payloads through complex biological barriers to prevent and treat vector-borne diseases, neuronal disorders, and cancer. [Display omitted] |
| doi_str_mv | 10.1016/j.jconrel.2015.08.039 |
| format | Article |
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Nanocarriers functionalized with active and passive targeting strategies enable the efficient delivery of diverse payloads through complex biological barriers to prevent and treat vector-borne diseases, neuronal disorders, and cancer. 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| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2015-12, Vol.219, p.548-559 |
| issn | 0168-3659 1873-4995 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animal Shells - metabolism Animals Biological barriers Blood–brain barrier Brain - metabolism Drug Carriers - administration & dosage Drug delivery Nanoparticle Nanoparticles - administration & dosage Neoplasms - metabolism Tumor microenvironment Vector-borne disease |
| title | Nano-enabled delivery of diverse payloads across complex biological barriers |
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