Prediction and validation of enzyme and transporter off-targets for metformin

Metformin, an established first-line treatment for patients with type 2 diabetes, has been associated with gastrointestinal (GI) adverse effects that limit its use. Histamine and serotonin have potent effects on the GI tract. The effects of metformin on histamine and serotonin uptake were evaluated...

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Veröffentlicht in:	Journal of pharmacokinetics and pharmacodynamics 2015-10, Vol.42 (5), p.463-475
Hauptverfasser:	Yee, Sook Wah, Lin, Lawrence, Merski, Matthew, Keiser, Michael J., Gupta, Aakash, Zhang, Youcai, Chien, Huan-Chieh, Shoichet, Brian K., Giacomini, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amine Oxidase (Copper-Containing) - metabolism Biochemistry Biological Transport - physiology Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Cell Line Diabetes Mellitus, Type 2 - metabolism HEK293 Cells Humans Intestinal Mucosa - metabolism Kinetics Membrane Transport Proteins - metabolism Metformin - metabolism Octamer Transcription Factor-3 - metabolism Organic Cation Transporter 1 - metabolism Original Paper Pharmacology/Toxicology Pharmacy Serotonin Plasma Membrane Transport Proteins - metabolism Veterinary Medicine/Veterinary Science
Online-Zugang:	Volltext
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