Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet
Obesity is a multifactorial health problem resulting from genetic, environmental and behavioral factors. A particularly interesting aspect of obesity is the differences observed in response to the same high-fat diet (HFD). In this study, we performed lipidomic profiling on livers from HFD-fed C57BL/...
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| Veröffentlicht in: | Scientific reports 2015-11, Vol.5 (1), p.16984-16984, Article 16984 |
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| creator | Nam, Miso Choi, Myung-Sook Jung, Sunhee Jung, Youngae Choi, Ji-Young Ryu, Do Hyun Hwang, Geum-Sook |
| description | Obesity is a multifactorial health problem resulting from genetic, environmental and behavioral factors. A particularly interesting aspect of obesity is the differences observed in response to the same high-fat diet (HFD). In this study, we performed lipidomic profiling on livers from HFD-fed C57BL/6J mice using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry. Mice were divided into three groups: normal diet (ND), HFD-obesity prone (HFD-OP) and HFD-obesity resistant (HFD-OR). Principal components analyses showed a difference between the HFD-OP and HFD-OR groups. Individuals in the HFD-OR group were closer to those in the ND group compared with those in the HFD-OP group. In particular, phosphocholine (PC) and triglyceride (TG) levels differed significantly depending on the length of the acyl chain and degree of unsaturation, respectively. PC species were either positively or negatively correlated with concentrations of glucose, insulin, leptin and hepatic cholesterol according to the length of the acyl chain. Decreased expression of the scavenger receptor B1 and ATP-binding cassette A1 in HFD-OP mice indicated that the acyl chain length of PC species may be related to high-density lipoprotein cholesterol metabolism. This study demonstrates that lipidomic profiling is an effective approach to analyzing global lipid alterations as they pertain to obesity. |
| doi_str_mv | 10.1038/srep16984 |
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A particularly interesting aspect of obesity is the differences observed in response to the same high-fat diet (HFD). In this study, we performed lipidomic profiling on livers from HFD-fed C57BL/6J mice using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry. Mice were divided into three groups: normal diet (ND), HFD-obesity prone (HFD-OP) and HFD-obesity resistant (HFD-OR). Principal components analyses showed a difference between the HFD-OP and HFD-OR groups. Individuals in the HFD-OR group were closer to those in the ND group compared with those in the HFD-OP group. In particular, phosphocholine (PC) and triglyceride (TG) levels differed significantly depending on the length of the acyl chain and degree of unsaturation, respectively. PC species were either positively or negatively correlated with concentrations of glucose, insulin, leptin and hepatic cholesterol according to the length of the acyl chain. Decreased expression of the scavenger receptor B1 and ATP-binding cassette A1 in HFD-OP mice indicated that the acyl chain length of PC species may be related to high-density lipoprotein cholesterol metabolism. This study demonstrates that lipidomic profiling is an effective approach to analyzing global lipid alterations as they pertain to obesity.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep16984</identifier><identifier>PMID: 26592433</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/1647/296 ; 631/45/320 ; 631/45/608 ; 64/60 ; Animals ; ATP Binding Cassette Transporter 1 - genetics ; ATP Binding Cassette Transporter 1 - metabolism ; Cholesterol ; Cholesterol - metabolism ; Chromatography, High Pressure Liquid ; Diet ; Diet, High-Fat - adverse effects ; Gene Expression ; Glucose - metabolism ; High fat diet ; Humanities and Social Sciences ; Insulin ; Insulin - metabolism ; Leptin ; Leptin - metabolism ; Lipid metabolism ; Lipid Metabolism - genetics ; Liquid chromatography ; Liver ; Liver - metabolism ; Liver - pathology ; Male ; Mass spectrometry ; Mass spectroscopy ; Metabolome - genetics ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; multidisciplinary ; Obesity ; Obesity - etiology ; Obesity - genetics ; Obesity - metabolism ; Obesity - pathology ; Phosphocholine ; Phosphorylcholine - metabolism ; Principal Component Analysis ; Rodents ; Scavenger receptors ; Scavenger Receptors, Class B - genetics ; Scavenger Receptors, Class B - metabolism ; Science ; Species Specificity ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Triglycerides - metabolism</subject><ispartof>Scientific reports, 2015-11, Vol.5 (1), p.16984-16984, Article 16984</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Nov 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-8d4f1a66da2c4d0c702015a0409622c84b818f85b43ccc7e2bba8f7538644433</citedby><cites>FETCH-LOGICAL-c504t-8d4f1a66da2c4d0c702015a0409622c84b818f85b43ccc7e2bba8f7538644433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655311/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655311/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26592433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nam, Miso</creatorcontrib><creatorcontrib>Choi, Myung-Sook</creatorcontrib><creatorcontrib>Jung, Sunhee</creatorcontrib><creatorcontrib>Jung, Youngae</creatorcontrib><creatorcontrib>Choi, Ji-Young</creatorcontrib><creatorcontrib>Ryu, Do Hyun</creatorcontrib><creatorcontrib>Hwang, Geum-Sook</creatorcontrib><title>Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Obesity is a multifactorial health problem resulting from genetic, environmental and behavioral factors. A particularly interesting aspect of obesity is the differences observed in response to the same high-fat diet (HFD). In this study, we performed lipidomic profiling on livers from HFD-fed C57BL/6J mice using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry. Mice were divided into three groups: normal diet (ND), HFD-obesity prone (HFD-OP) and HFD-obesity resistant (HFD-OR). Principal components analyses showed a difference between the HFD-OP and HFD-OR groups. Individuals in the HFD-OR group were closer to those in the ND group compared with those in the HFD-OP group. In particular, phosphocholine (PC) and triglyceride (TG) levels differed significantly depending on the length of the acyl chain and degree of unsaturation, respectively. PC species were either positively or negatively correlated with concentrations of glucose, insulin, leptin and hepatic cholesterol according to the length of the acyl chain. Decreased expression of the scavenger receptor B1 and ATP-binding cassette A1 in HFD-OP mice indicated that the acyl chain length of PC species may be related to high-density lipoprotein cholesterol metabolism. This study demonstrates that lipidomic profiling is an effective approach to analyzing global lipid alterations as they pertain to obesity.</description><subject>631/1647/296</subject><subject>631/45/320</subject><subject>631/45/608</subject><subject>64/60</subject><subject>Animals</subject><subject>ATP Binding Cassette Transporter 1 - genetics</subject><subject>ATP Binding Cassette Transporter 1 - metabolism</subject><subject>Cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Gene Expression</subject><subject>Glucose - metabolism</subject><subject>High fat diet</subject><subject>Humanities and Social Sciences</subject><subject>Insulin</subject><subject>Insulin - metabolism</subject><subject>Leptin</subject><subject>Leptin - metabolism</subject><subject>Lipid metabolism</subject><subject>Lipid Metabolism - genetics</subject><subject>Liquid chromatography</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metabolome - genetics</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Obese</subject><subject>multidisciplinary</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - genetics</subject><subject>Obesity - metabolism</subject><subject>Obesity - pathology</subject><subject>Phosphocholine</subject><subject>Phosphorylcholine - metabolism</subject><subject>Principal Component Analysis</subject><subject>Rodents</subject><subject>Scavenger receptors</subject><subject>Scavenger Receptors, Class B - genetics</subject><subject>Scavenger Receptors, Class B - metabolism</subject><subject>Science</subject><subject>Species Specificity</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Triglycerides - metabolism</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkdFK7DAQhoMoKqsXvoAEvNED1SRN2vRGED2rB1YU2fuQptM10iZr0gq-vZHVZY_OzQyZj39m8iN0RMk5Jbm8iAGWtKgk30L7jHCRsZyx7Y16Dx3G-EJSCFZxWu2iPVaIivE830cws0vb-N4a_Bh8azvrFti3eGbfIOC5jXEE3Abf44caoh3es4Q5wNo165enlOKg3YDvrQE8hQZrfGcXz3iqB3xjYThAO63uIhx-5QmaT__Or--y2cPtv-urWWYE4UMmG95SXRSNZoY3xJSEESo04aQqGDOS15LKVoqa58aYElhda9mWIpcF5-mcCbpcyS7HuofGgBuC7tQy2F6Hd-W1Vf93nH1WC_-meCFETmkSOP0SCP51hDio3kYDXacd-DEqWuYFp-yTnqCTH-iLH4NL1ykqq0qSqkw_PEFnK8oEH5NT7XoZStSnfWptX2KPN7dfk99mJeDPCoip5RYQNkb-UvsABtKjNg</recordid><startdate>20151123</startdate><enddate>20151123</enddate><creator>Nam, Miso</creator><creator>Choi, Myung-Sook</creator><creator>Jung, Sunhee</creator><creator>Jung, Youngae</creator><creator>Choi, Ji-Young</creator><creator>Ryu, Do Hyun</creator><creator>Hwang, Geum-Sook</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151123</creationdate><title>Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet</title><author>Nam, Miso ; Choi, Myung-Sook ; Jung, Sunhee ; Jung, Youngae ; Choi, Ji-Young ; Ryu, Do Hyun ; Hwang, Geum-Sook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-8d4f1a66da2c4d0c702015a0409622c84b818f85b43ccc7e2bba8f7538644433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>631/1647/296</topic><topic>631/45/320</topic><topic>631/45/608</topic><topic>64/60</topic><topic>Animals</topic><topic>ATP Binding Cassette Transporter 1 - genetics</topic><topic>ATP Binding Cassette Transporter 1 - metabolism</topic><topic>Cholesterol</topic><topic>Cholesterol - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Gene Expression</topic><topic>Glucose - metabolism</topic><topic>High fat diet</topic><topic>Humanities and Social Sciences</topic><topic>Insulin</topic><topic>Insulin - metabolism</topic><topic>Leptin</topic><topic>Leptin - metabolism</topic><topic>Lipid metabolism</topic><topic>Lipid Metabolism - genetics</topic><topic>Liquid chromatography</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Metabolome - genetics</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Obese</topic><topic>multidisciplinary</topic><topic>Obesity</topic><topic>Obesity - etiology</topic><topic>Obesity - genetics</topic><topic>Obesity - metabolism</topic><topic>Obesity - pathology</topic><topic>Phosphocholine</topic><topic>Phosphorylcholine - metabolism</topic><topic>Principal Component Analysis</topic><topic>Rodents</topic><topic>Scavenger receptors</topic><topic>Scavenger Receptors, Class B - genetics</topic><topic>Scavenger Receptors, Class B - metabolism</topic><topic>Science</topic><topic>Species Specificity</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nam, Miso</creatorcontrib><creatorcontrib>Choi, Myung-Sook</creatorcontrib><creatorcontrib>Jung, Sunhee</creatorcontrib><creatorcontrib>Jung, Youngae</creatorcontrib><creatorcontrib>Choi, Ji-Young</creatorcontrib><creatorcontrib>Ryu, Do Hyun</creatorcontrib><creatorcontrib>Hwang, Geum-Sook</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nam, Miso</au><au>Choi, Myung-Sook</au><au>Jung, Sunhee</au><au>Jung, Youngae</au><au>Choi, Ji-Young</au><au>Ryu, Do Hyun</au><au>Hwang, Geum-Sook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-11-23</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>16984</spage><epage>16984</epage><pages>16984-16984</pages><artnum>16984</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Obesity is a multifactorial health problem resulting from genetic, environmental and behavioral factors. A particularly interesting aspect of obesity is the differences observed in response to the same high-fat diet (HFD). In this study, we performed lipidomic profiling on livers from HFD-fed C57BL/6J mice using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry. Mice were divided into three groups: normal diet (ND), HFD-obesity prone (HFD-OP) and HFD-obesity resistant (HFD-OR). Principal components analyses showed a difference between the HFD-OP and HFD-OR groups. Individuals in the HFD-OR group were closer to those in the ND group compared with those in the HFD-OP group. In particular, phosphocholine (PC) and triglyceride (TG) levels differed significantly depending on the length of the acyl chain and degree of unsaturation, respectively. PC species were either positively or negatively correlated with concentrations of glucose, insulin, leptin and hepatic cholesterol according to the length of the acyl chain. Decreased expression of the scavenger receptor B1 and ATP-binding cassette A1 in HFD-OP mice indicated that the acyl chain length of PC species may be related to high-density lipoprotein cholesterol metabolism. This study demonstrates that lipidomic profiling is an effective approach to analyzing global lipid alterations as they pertain to obesity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26592433</pmid><doi>10.1038/srep16984</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/1647/296 631/45/320 631/45/608 64/60 Animals ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter 1 - metabolism Cholesterol Cholesterol - metabolism Chromatography, High Pressure Liquid Diet Diet, High-Fat - adverse effects Gene Expression Glucose - metabolism High fat diet Humanities and Social Sciences Insulin Insulin - metabolism Leptin Leptin - metabolism Lipid metabolism Lipid Metabolism - genetics Liquid chromatography Liver Liver - metabolism Liver - pathology Male Mass spectrometry Mass spectroscopy Metabolome - genetics Mice Mice, Inbred C57BL Mice, Obese multidisciplinary Obesity Obesity - etiology Obesity - genetics Obesity - metabolism Obesity - pathology Phosphocholine Phosphorylcholine - metabolism Principal Component Analysis Rodents Scavenger receptors Scavenger Receptors, Class B - genetics Scavenger Receptors, Class B - metabolism Science Species Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Triglycerides - metabolism |
| title | Lipidomic Profiling of Liver Tissue from Obesity-Prone and Obesity-Resistant Mice Fed a High Fat Diet |
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