Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects
The etiologies of conjugated hyperbilirubinemia in infancy are diverse. Determine the prevalence rates of the specific etiologies of conjugated hyperbilirubinemia in infancy. EMBASE and Pubmed were searched electronically and the bibliographies of selected studies were search manually. The search wa...
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| Veröffentlicht in: | BMC pediatrics 2015-11, Vol.15 (192), p.192-192, Article 192 |
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| creator | Gottesman, Lena E Del Vecchio, Michael T Aronoff, Stephen C |
| description | The etiologies of conjugated hyperbilirubinemia in infancy are diverse.
Determine the prevalence rates of the specific etiologies of conjugated hyperbilirubinemia in infancy.
EMBASE and Pubmed were searched electronically and the bibliographies of selected studies were search manually. The search was conducted independently by two authors.
(1) prospective or retrospective case series or cohort study with 10 or more subjects; (2) consecutive infants who presented with conjugated hyperbilirubinemia; (3) subjects underwent appropriate diagnostic work-up for conjugated hyperbilirubinemia; (4) no specific diagnoses were excluded in the studied cohort.
Patient number, age range, country of origin, and categorical and specific etiologies.
From 237 studies identified, 17 studies encompassing 1692 infants were selected. Idiopathic neonatal hepatitis (INH) occurred in 26.0% of cases; the most common specific etiologies were extrahepatic biliary atresia (EHBA) (25.89%), infection (11.47%), TPN- associated cholestasis (6.44%), metabolic disease (4.37%), alpha-1 anti-trypsin deficiency (4.14%), and perinatal hypoxia/ischemia (3.66%). CMV was the most common infection identified (31.51%) and galactosemia (36.49%) was the most common metabolic disease identified.
Major limitations are: (1) inconsistencies in the diagnostic evaluations among the different studies and (2) variations among the sample populations.
INH is the most common diagnosis for conjugated hyperbilirubinemia in infancy while EHBA and infection are the most commonly identified etiologies. The present review is intended to be a guide to the differential diagnosis and evaluation of the infant presenting with conjugated hyperbilirubinemia. |
| doi_str_mv | 10.1186/s12887-015-0506-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4654877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A449506494</galeid><sourcerecordid>A449506494</sourcerecordid><originalsourceid>FETCH-LOGICAL-c553t-a2cdc99977f1f1ba0ee884010b85f2a420a8cc529afed45e0b668a79b6f565863</originalsourceid><addsrcrecordid>eNp9Ul2L1DAUDaK4H_oDfJGCIL50TdJ8-rCwLLsqLPiib0JI05uZDG0zJu3K_HtTZl1nRCSBhOSck9xzD0KvCL4gRIn3mVClZI0JrzHHouZP0ClhktSUNeTpwf4EneW8wZhIxcRzdEIFV1pzfYq-30wh9nEVIFfRVy6Om3llJ-iq9W4LqQ19SHMbRhiCrcJYprej232obJV3eYLBTsFVCe4D_FwEiNC0ynO7ATflF-iZt32Glw_rOfp2e_P1-lN99-Xj5-uru9px3ky1pa5zWmspPfGktRhAKYYJbhX31DKKrXKOU209dIwDboVQVupWeF4KEc05utzrbud2gM7BOCXbm20Kg007E20wxzdjWJtVvDdMcKakLALvHgRS_DFDnswQsoO-tyPEORsiG66xbBQp0Dd_QTdxTmMpz9BitWyEZM3_UERKLRSXjP1BrWwPplgby-_c8rS5YkyXljK9oC7-gSqjK00pDQMfyvkR4e0BYQ22n9Y59nPp9JiPgWQPdCnmnMA_WkawWRJm9gkzJWFmSZjhhfP60OtHxu9INb8AHw7Jzg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779685744</pqid></control><display><type>article</type><title>Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Gottesman, Lena E ; Del Vecchio, Michael T ; Aronoff, Stephen C</creator><creatorcontrib>Gottesman, Lena E ; Del Vecchio, Michael T ; Aronoff, Stephen C</creatorcontrib><description>The etiologies of conjugated hyperbilirubinemia in infancy are diverse.
Determine the prevalence rates of the specific etiologies of conjugated hyperbilirubinemia in infancy.
EMBASE and Pubmed were searched electronically and the bibliographies of selected studies were search manually. The search was conducted independently by two authors.
(1) prospective or retrospective case series or cohort study with 10 or more subjects; (2) consecutive infants who presented with conjugated hyperbilirubinemia; (3) subjects underwent appropriate diagnostic work-up for conjugated hyperbilirubinemia; (4) no specific diagnoses were excluded in the studied cohort.
Patient number, age range, country of origin, and categorical and specific etiologies.
From 237 studies identified, 17 studies encompassing 1692 infants were selected. Idiopathic neonatal hepatitis (INH) occurred in 26.0% of cases; the most common specific etiologies were extrahepatic biliary atresia (EHBA) (25.89%), infection (11.47%), TPN- associated cholestasis (6.44%), metabolic disease (4.37%), alpha-1 anti-trypsin deficiency (4.14%), and perinatal hypoxia/ischemia (3.66%). CMV was the most common infection identified (31.51%) and galactosemia (36.49%) was the most common metabolic disease identified.
Major limitations are: (1) inconsistencies in the diagnostic evaluations among the different studies and (2) variations among the sample populations.
INH is the most common diagnosis for conjugated hyperbilirubinemia in infancy while EHBA and infection are the most commonly identified etiologies. The present review is intended to be a guide to the differential diagnosis and evaluation of the infant presenting with conjugated hyperbilirubinemia.</description><identifier>ISSN: 1471-2431</identifier><identifier>EISSN: 1471-2431</identifier><identifier>DOI: 10.1186/s12887-015-0506-5</identifier><identifier>PMID: 26589959</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Bile ; Care and treatment ; Complications and side effects ; Cysts ; Data collection ; Development and progression ; Diagnosis, Differential ; Disease ; Etiology ; Evidence-based medicine ; Gallbladder diseases ; Health aspects ; Hepatitis ; Humans ; Hyperbilirubinemia ; Hyperbilirubinemia - diagnosis ; Hyperbilirubinemia - etiology ; Infant ; Infant, Newborn ; Infants ; Infections ; Jaundice ; Metabolic disorders ; Newborn babies ; Parenteral nutrition ; Patients ; Systematic review ; Trypsin</subject><ispartof>BMC pediatrics, 2015-11, Vol.15 (192), p.192-192, Article 192</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>2015. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Gottesman et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-a2cdc99977f1f1ba0ee884010b85f2a420a8cc529afed45e0b668a79b6f565863</citedby><cites>FETCH-LOGICAL-c553t-a2cdc99977f1f1ba0ee884010b85f2a420a8cc529afed45e0b668a79b6f565863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654877/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654877/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26589959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gottesman, Lena E</creatorcontrib><creatorcontrib>Del Vecchio, Michael T</creatorcontrib><creatorcontrib>Aronoff, Stephen C</creatorcontrib><title>Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects</title><title>BMC pediatrics</title><addtitle>BMC Pediatr</addtitle><description>The etiologies of conjugated hyperbilirubinemia in infancy are diverse.
Determine the prevalence rates of the specific etiologies of conjugated hyperbilirubinemia in infancy.
EMBASE and Pubmed were searched electronically and the bibliographies of selected studies were search manually. The search was conducted independently by two authors.
(1) prospective or retrospective case series or cohort study with 10 or more subjects; (2) consecutive infants who presented with conjugated hyperbilirubinemia; (3) subjects underwent appropriate diagnostic work-up for conjugated hyperbilirubinemia; (4) no specific diagnoses were excluded in the studied cohort.
Patient number, age range, country of origin, and categorical and specific etiologies.
From 237 studies identified, 17 studies encompassing 1692 infants were selected. Idiopathic neonatal hepatitis (INH) occurred in 26.0% of cases; the most common specific etiologies were extrahepatic biliary atresia (EHBA) (25.89%), infection (11.47%), TPN- associated cholestasis (6.44%), metabolic disease (4.37%), alpha-1 anti-trypsin deficiency (4.14%), and perinatal hypoxia/ischemia (3.66%). CMV was the most common infection identified (31.51%) and galactosemia (36.49%) was the most common metabolic disease identified.
Major limitations are: (1) inconsistencies in the diagnostic evaluations among the different studies and (2) variations among the sample populations.
INH is the most common diagnosis for conjugated hyperbilirubinemia in infancy while EHBA and infection are the most commonly identified etiologies. The present review is intended to be a guide to the differential diagnosis and evaluation of the infant presenting with conjugated hyperbilirubinemia.</description><subject>Bile</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Cysts</subject><subject>Data collection</subject><subject>Development and progression</subject><subject>Diagnosis, Differential</subject><subject>Disease</subject><subject>Etiology</subject><subject>Evidence-based medicine</subject><subject>Gallbladder diseases</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Hyperbilirubinemia</subject><subject>Hyperbilirubinemia - diagnosis</subject><subject>Hyperbilirubinemia - etiology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infections</subject><subject>Jaundice</subject><subject>Metabolic disorders</subject><subject>Newborn babies</subject><subject>Parenteral nutrition</subject><subject>Patients</subject><subject>Systematic review</subject><subject>Trypsin</subject><issn>1471-2431</issn><issn>1471-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9Ul2L1DAUDaK4H_oDfJGCIL50TdJ8-rCwLLsqLPiib0JI05uZDG0zJu3K_HtTZl1nRCSBhOSck9xzD0KvCL4gRIn3mVClZI0JrzHHouZP0ClhktSUNeTpwf4EneW8wZhIxcRzdEIFV1pzfYq-30wh9nEVIFfRVy6Om3llJ-iq9W4LqQ19SHMbRhiCrcJYprej232obJV3eYLBTsFVCe4D_FwEiNC0ynO7ATflF-iZt32Glw_rOfp2e_P1-lN99-Xj5-uru9px3ky1pa5zWmspPfGktRhAKYYJbhX31DKKrXKOU209dIwDboVQVupWeF4KEc05utzrbud2gM7BOCXbm20Kg007E20wxzdjWJtVvDdMcKakLALvHgRS_DFDnswQsoO-tyPEORsiG66xbBQp0Dd_QTdxTmMpz9BitWyEZM3_UERKLRSXjP1BrWwPplgby-_c8rS5YkyXljK9oC7-gSqjK00pDQMfyvkR4e0BYQ22n9Y59nPp9JiPgWQPdCnmnMA_WkawWRJm9gkzJWFmSZjhhfP60OtHxu9INb8AHw7Jzg</recordid><startdate>20151120</startdate><enddate>20151120</enddate><creator>Gottesman, Lena E</creator><creator>Del Vecchio, Michael T</creator><creator>Aronoff, Stephen C</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151120</creationdate><title>Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects</title><author>Gottesman, Lena E ; Del Vecchio, Michael T ; Aronoff, Stephen C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-a2cdc99977f1f1ba0ee884010b85f2a420a8cc529afed45e0b668a79b6f565863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Bile</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Cysts</topic><topic>Data collection</topic><topic>Development and progression</topic><topic>Diagnosis, Differential</topic><topic>Disease</topic><topic>Etiology</topic><topic>Evidence-based medicine</topic><topic>Gallbladder diseases</topic><topic>Health aspects</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Hyperbilirubinemia</topic><topic>Hyperbilirubinemia - diagnosis</topic><topic>Hyperbilirubinemia - etiology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infections</topic><topic>Jaundice</topic><topic>Metabolic disorders</topic><topic>Newborn babies</topic><topic>Parenteral nutrition</topic><topic>Patients</topic><topic>Systematic review</topic><topic>Trypsin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gottesman, Lena E</creatorcontrib><creatorcontrib>Del Vecchio, Michael T</creatorcontrib><creatorcontrib>Aronoff, Stephen C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gottesman, Lena E</au><au>Del Vecchio, Michael T</au><au>Aronoff, Stephen C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects</atitle><jtitle>BMC pediatrics</jtitle><addtitle>BMC Pediatr</addtitle><date>2015-11-20</date><risdate>2015</risdate><volume>15</volume><issue>192</issue><spage>192</spage><epage>192</epage><pages>192-192</pages><artnum>192</artnum><issn>1471-2431</issn><eissn>1471-2431</eissn><abstract>The etiologies of conjugated hyperbilirubinemia in infancy are diverse.
Determine the prevalence rates of the specific etiologies of conjugated hyperbilirubinemia in infancy.
EMBASE and Pubmed were searched electronically and the bibliographies of selected studies were search manually. The search was conducted independently by two authors.
(1) prospective or retrospective case series or cohort study with 10 or more subjects; (2) consecutive infants who presented with conjugated hyperbilirubinemia; (3) subjects underwent appropriate diagnostic work-up for conjugated hyperbilirubinemia; (4) no specific diagnoses were excluded in the studied cohort.
Patient number, age range, country of origin, and categorical and specific etiologies.
From 237 studies identified, 17 studies encompassing 1692 infants were selected. Idiopathic neonatal hepatitis (INH) occurred in 26.0% of cases; the most common specific etiologies were extrahepatic biliary atresia (EHBA) (25.89%), infection (11.47%), TPN- associated cholestasis (6.44%), metabolic disease (4.37%), alpha-1 anti-trypsin deficiency (4.14%), and perinatal hypoxia/ischemia (3.66%). CMV was the most common infection identified (31.51%) and galactosemia (36.49%) was the most common metabolic disease identified.
Major limitations are: (1) inconsistencies in the diagnostic evaluations among the different studies and (2) variations among the sample populations.
INH is the most common diagnosis for conjugated hyperbilirubinemia in infancy while EHBA and infection are the most commonly identified etiologies. The present review is intended to be a guide to the differential diagnosis and evaluation of the infant presenting with conjugated hyperbilirubinemia.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26589959</pmid><doi>10.1186/s12887-015-0506-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central; Springer Nature OA/Free Journals; SpringerLink Journals - AutoHoldings |
| subjects | Bile Care and treatment Complications and side effects Cysts Data collection Development and progression Diagnosis, Differential Disease Etiology Evidence-based medicine Gallbladder diseases Health aspects Hepatitis Humans Hyperbilirubinemia Hyperbilirubinemia - diagnosis Hyperbilirubinemia - etiology Infant Infant, Newborn Infants Infections Jaundice Metabolic disorders Newborn babies Parenteral nutrition Patients Systematic review Trypsin |
| title | Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects |
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