Implications of microbiota and bile acid in liver injury and regeneration
Summary Studies examining the mechanisms by which the liver incurs injury and then regenerates usually focus on factors and pathways directly within the liver, neglecting the signaling derived from the gut-liver axis. The intestinal content is rich in microorganisms as well as metabolites generated...
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| Veröffentlicht in: | Journal of hepatology 2015-12, Vol.63 (6), p.1502-1510 |
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| creator | Liu, Hui-Xin Keane, Ryan Sheng, Lili Wan, Yu-Jui Yvonne |
| description | Summary Studies examining the mechanisms by which the liver incurs injury and then regenerates usually focus on factors and pathways directly within the liver, neglecting the signaling derived from the gut-liver axis. The intestinal content is rich in microorganisms as well as metabolites generated from both the host and colonizing bacteria. Through the gut-liver axis, this complex “soup” exerts an immense impact on liver integrity and function. This review article summarizes data published in the past 30 years demonstrating the signaling derived from the gut-liver axis in relation to liver injury and regeneration. Due to the intricate networks of implicated pathways as well as scarcity of available mechanistic data, it seems that nutrigenomic, metabolomics, and microbiota profiling approaches are warranted to provide a better understanding regarding the interplay and impact between nutrition, bacteria, and host response in influencing liver function and healing. Therefore elucidating the possible molecular mechanisms that link microbiota alteration to host physiological response and vice versa. |
| doi_str_mv | 10.1016/j.jhep.2015.08.001 |
| format | Article |
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The intestinal content is rich in microorganisms as well as metabolites generated from both the host and colonizing bacteria. Through the gut-liver axis, this complex “soup” exerts an immense impact on liver integrity and function. This review article summarizes data published in the past 30 years demonstrating the signaling derived from the gut-liver axis in relation to liver injury and regeneration. Due to the intricate networks of implicated pathways as well as scarcity of available mechanistic data, it seems that nutrigenomic, metabolomics, and microbiota profiling approaches are warranted to provide a better understanding regarding the interplay and impact between nutrition, bacteria, and host response in influencing liver function and healing. 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The intestinal content is rich in microorganisms as well as metabolites generated from both the host and colonizing bacteria. Through the gut-liver axis, this complex “soup” exerts an immense impact on liver integrity and function. This review article summarizes data published in the past 30 years demonstrating the signaling derived from the gut-liver axis in relation to liver injury and regeneration. Due to the intricate networks of implicated pathways as well as scarcity of available mechanistic data, it seems that nutrigenomic, metabolomics, and microbiota profiling approaches are warranted to provide a better understanding regarding the interplay and impact between nutrition, bacteria, and host response in influencing liver function and healing. Therefore elucidating the possible molecular mechanisms that link microbiota alteration to host physiological response and vice versa.</description><subject>Bile acid receptor</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Endotoxins - physiology</subject><subject>FXR</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Gut dysbiosis</subject><subject>Gut-liver axis</subject><subject>Humans</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Intestinal Mucosa - physiopathology</subject><subject>Liver - injuries</subject><subject>Liver - microbiology</subject><subject>Liver - physiology</subject><subject>Liver Regeneration - physiology</subject><subject>Microbiota - physiology</subject><subject>Models, Biological</subject><subject>Nuclear receptor</subject><subject>Partial hepatectomy</subject><subject>Prebiotic</subject><subject>Probiotic</subject><subject>Probiotics - therapeutic use</subject><subject>Signal Transduction</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk1v1DAQtRCILoU_wAHlyCVh_BHHK6FKqAK6UiUOwNlynEnrkNiLnay0_75Ot1SFA5IlW5r33ozfG0LeUqgoUPlhqIZb3FcMaF2BqgDoM7KhEqAEKehzsskgVSrWqDPyKqUBADhsxUtyxiSrpeDNhux203501swu-FSEvpicjaF1YTaF8V3RuhELY11XOF-M7oAxP4YlHu-rEW_QY7xnvyYvejMmfPNwn5OfXz7_uLwqr7993V1-ui5t3ci5tJw1LZNIVc-ZyuNQNNBYabHtBNhaKqHA9ALbhm07tLxva7tlgrKma4Wi_JxcnHT3SzthZ9HP0Yx6H91k4lEH4_TfFe9u9U04aCHrfHgWeP8gEMPvBdOsJ5csjqPxGJakacNrziRVMkPZCZo9SSli_9iGgl4z0INeM9BrBhqUzhlk0runAz5S_pieAR9PAMw2HRxGnaxDb7FzEe2su-D-r3_xD92OzucMx194xDSEJfocgKY6MQ36-7oF6xLQGiB_X_A7Fpit9Q</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Liu, Hui-Xin</creator><creator>Keane, Ryan</creator><creator>Sheng, Lili</creator><creator>Wan, Yu-Jui Yvonne</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>Implications of microbiota and bile acid in liver injury and regeneration</title><author>Liu, Hui-Xin ; Keane, Ryan ; Sheng, Lili ; Wan, Yu-Jui Yvonne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-c327b26e18f3280941ea07c6cebd40c568480af4eb729dec3fb5c924127db4813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Bile acid receptor</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Endotoxins - physiology</topic><topic>FXR</topic><topic>Gastroenterology and Hepatology</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Gut dysbiosis</topic><topic>Gut-liver axis</topic><topic>Humans</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Intestinal Mucosa - physiopathology</topic><topic>Liver - injuries</topic><topic>Liver - microbiology</topic><topic>Liver - physiology</topic><topic>Liver Regeneration - physiology</topic><topic>Microbiota - physiology</topic><topic>Models, Biological</topic><topic>Nuclear receptor</topic><topic>Partial hepatectomy</topic><topic>Prebiotic</topic><topic>Probiotic</topic><topic>Probiotics - therapeutic use</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Hui-Xin</creatorcontrib><creatorcontrib>Keane, Ryan</creatorcontrib><creatorcontrib>Sheng, Lili</creatorcontrib><creatorcontrib>Wan, Yu-Jui Yvonne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Hui-Xin</au><au>Keane, Ryan</au><au>Sheng, Lili</au><au>Wan, Yu-Jui Yvonne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implications of microbiota and bile acid in liver injury and regeneration</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>63</volume><issue>6</issue><spage>1502</spage><epage>1510</epage><pages>1502-1510</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><abstract>Summary Studies examining the mechanisms by which the liver incurs injury and then regenerates usually focus on factors and pathways directly within the liver, neglecting the signaling derived from the gut-liver axis. 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Therefore elucidating the possible molecular mechanisms that link microbiota alteration to host physiological response and vice versa.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26256437</pmid><doi>10.1016/j.jhep.2015.08.001</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of hepatology, 2015-12, Vol.63 (6), p.1502-1510 |
| issn | 0168-8278 1600-0641 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Bile acid receptor Bile Acids and Salts - metabolism Endotoxins - physiology FXR Gastroenterology and Hepatology Gastrointestinal Microbiome - physiology Gut dysbiosis Gut-liver axis Humans Intestinal Mucosa - microbiology Intestinal Mucosa - physiopathology Liver - injuries Liver - microbiology Liver - physiology Liver Regeneration - physiology Microbiota - physiology Models, Biological Nuclear receptor Partial hepatectomy Prebiotic Probiotic Probiotics - therapeutic use Signal Transduction |
| title | Implications of microbiota and bile acid in liver injury and regeneration |
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