Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study

ObjectivesPeripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary fa...

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Veröffentlicht in:BMJ open 2015-11, Vol.5 (11), p.e009305-e009305
Hauptverfasser: Lian, Fuzhi, Wang, Jinquan, Huang, Xianhong, Wu, Yinyin, Cao, Yifei, Tan, Xiaohua, Xu, Xianrong, Hong, Yu, Yang, Lei, Gao, Xiang
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container_issue 11
container_start_page e009305
container_title BMJ open
container_volume 5
creator Lian, Fuzhi
Wang, Jinquan
Huang, Xianhong
Wu, Yinyin
Cao, Yifei
Tan, Xiaohua
Xu, Xianrong
Hong, Yu
Yang, Lei
Gao, Xiang
description ObjectivesPeripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk.Study designA community-based case–control study.Participants271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China.Outcome measuresPeripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests.ResultsAmong controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p
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Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk.Study designA community-based case–control study.Participants271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China.Outcome measuresPeripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests.ResultsAmong controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p&lt;0.001), but not in those with lower vegetable intake (P-interaction=0.008).ConclusionsCertain dietary factors might modify telomere-related hypertension risk.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2015-009305</identifier><identifier>PMID: 26560064</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Age ; Aged ; Aging - physiology ; Antihypertensives ; Blood pressure ; Body mass index ; Case-Control Studies ; China ; Cholesterol ; Chronic illnesses ; Community ; Diabetes ; Diet ; Feeding Behavior ; Female ; Food ; Gender ; High density lipoprotein ; Humans ; Hypertension ; Hypertension - genetics ; Hypertension - prevention &amp; control ; Leukocytes ; Logistic Models ; Male ; Middle Aged ; Nutrition and Metabolism ; Odds Ratio ; Oxidative stress ; Questionnaires ; Real-Time Polymerase Chain Reaction ; Risk Factors ; Smoking ; Surveys and Questionnaires ; Telomerase ; Telomere ; Telomere Shortening ; Thermal cycling ; Triglycerides ; Vegetables</subject><ispartof>BMJ open, 2015-11, Vol.5 (11), p.e009305-e009305</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ 2015 This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b468t-82bfce40f3387900bc35d6dc2f422f4b02602bc6e1d58c1d1927c2c6361a5a1b3</citedby><cites>FETCH-LOGICAL-b468t-82bfce40f3387900bc35d6dc2f422f4b02602bc6e1d58c1d1927c2c6361a5a1b3</cites><orcidid>0000-0002-0733-579X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bmjopen.bmj.com/content/5/11/e009305.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://bmjopen.bmj.com/content/5/11/e009305.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27538,27539,27913,27914,53780,53782,77360,77391</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26560064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lian, Fuzhi</creatorcontrib><creatorcontrib>Wang, Jinquan</creatorcontrib><creatorcontrib>Huang, Xianhong</creatorcontrib><creatorcontrib>Wu, Yinyin</creatorcontrib><creatorcontrib>Cao, Yifei</creatorcontrib><creatorcontrib>Tan, Xiaohua</creatorcontrib><creatorcontrib>Xu, Xianrong</creatorcontrib><creatorcontrib>Hong, Yu</creatorcontrib><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><title>Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description>ObjectivesPeripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk.Study designA community-based case–control study.Participants271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China.Outcome measuresPeripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests.ResultsAmong controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p&lt;0.001), but not in those with lower vegetable intake (P-interaction=0.008).ConclusionsCertain dietary factors might modify telomere-related hypertension risk.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Antihypertensives</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Cholesterol</subject><subject>Chronic illnesses</subject><subject>Community</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Food</subject><subject>Gender</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - genetics</subject><subject>Hypertension - prevention &amp; 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control</topic><topic>Leukocytes</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nutrition and Metabolism</topic><topic>Odds Ratio</topic><topic>Oxidative stress</topic><topic>Questionnaires</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Surveys and Questionnaires</topic><topic>Telomerase</topic><topic>Telomere</topic><topic>Telomere Shortening</topic><topic>Thermal cycling</topic><topic>Triglycerides</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lian, Fuzhi</creatorcontrib><creatorcontrib>Wang, Jinquan</creatorcontrib><creatorcontrib>Huang, Xianhong</creatorcontrib><creatorcontrib>Wu, Yinyin</creatorcontrib><creatorcontrib>Cao, Yifei</creatorcontrib><creatorcontrib>Tan, Xiaohua</creatorcontrib><creatorcontrib>Xu, Xianrong</creatorcontrib><creatorcontrib>Hong, Yu</creatorcontrib><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; 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Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lian, Fuzhi</au><au>Wang, Jinquan</au><au>Huang, Xianhong</au><au>Wu, Yinyin</au><au>Cao, Yifei</au><au>Tan, Xiaohua</au><au>Xu, Xianrong</au><au>Hong, Yu</au><au>Yang, Lei</au><au>Gao, Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study</atitle><jtitle>BMJ open</jtitle><addtitle>BMJ Open</addtitle><date>2015-11-11</date><risdate>2015</risdate><volume>5</volume><issue>11</issue><spage>e009305</spage><epage>e009305</epage><pages>e009305-e009305</pages><issn>2044-6055</issn><eissn>2044-6055</eissn><abstract>ObjectivesPeripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk.Study designA community-based case–control study.Participants271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China.Outcome measuresPeripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests.ResultsAmong controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p&lt;0.001), but not in those with lower vegetable intake (P-interaction=0.008).ConclusionsCertain dietary factors might modify telomere-related hypertension risk.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>26560064</pmid><doi>10.1136/bmjopen-2015-009305</doi><orcidid>https://orcid.org/0000-0002-0733-579X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adult
Age
Aged
Aging - physiology
Antihypertensives
Blood pressure
Body mass index
Case-Control Studies
China
Cholesterol
Chronic illnesses
Community
Diabetes
Diet
Feeding Behavior
Female
Food
Gender
High density lipoprotein
Humans
Hypertension
Hypertension - genetics
Hypertension - prevention & control
Leukocytes
Logistic Models
Male
Middle Aged
Nutrition and Metabolism
Odds Ratio
Oxidative stress
Questionnaires
Real-Time Polymerase Chain Reaction
Risk Factors
Smoking
Surveys and Questionnaires
Telomerase
Telomere
Telomere Shortening
Thermal cycling
Triglycerides
Vegetables
title Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study
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