Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study
ObjectivesPeripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary fa...
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description | ObjectivesPeripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk.Study designA community-based case–control study.Participants271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China.Outcome measuresPeripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests.ResultsAmong controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p |
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Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk.Study designA community-based case–control study.Participants271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China.Outcome measuresPeripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests.ResultsAmong controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p<0.001), but not in those with lower vegetable intake (P-interaction=0.008).ConclusionsCertain dietary factors might modify telomere-related hypertension risk.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2015-009305</identifier><identifier>PMID: 26560064</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Age ; Aged ; Aging - physiology ; Antihypertensives ; Blood pressure ; Body mass index ; Case-Control Studies ; China ; Cholesterol ; Chronic illnesses ; Community ; Diabetes ; Diet ; Feeding Behavior ; Female ; Food ; Gender ; High density lipoprotein ; Humans ; Hypertension ; Hypertension - genetics ; Hypertension - prevention & control ; Leukocytes ; Logistic Models ; Male ; Middle Aged ; Nutrition and Metabolism ; Odds Ratio ; Oxidative stress ; Questionnaires ; Real-Time Polymerase Chain Reaction ; Risk Factors ; Smoking ; Surveys and Questionnaires ; Telomerase ; Telomere ; Telomere Shortening ; Thermal cycling ; Triglycerides ; Vegetables</subject><ispartof>BMJ open, 2015-11, Vol.5 (11), p.e009305-e009305</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ 2015 This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b468t-82bfce40f3387900bc35d6dc2f422f4b02602bc6e1d58c1d1927c2c6361a5a1b3</citedby><cites>FETCH-LOGICAL-b468t-82bfce40f3387900bc35d6dc2f422f4b02602bc6e1d58c1d1927c2c6361a5a1b3</cites><orcidid>0000-0002-0733-579X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bmjopen.bmj.com/content/5/11/e009305.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://bmjopen.bmj.com/content/5/11/e009305.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27538,27539,27913,27914,53780,53782,77360,77391</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26560064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lian, Fuzhi</creatorcontrib><creatorcontrib>Wang, Jinquan</creatorcontrib><creatorcontrib>Huang, Xianhong</creatorcontrib><creatorcontrib>Wu, Yinyin</creatorcontrib><creatorcontrib>Cao, Yifei</creatorcontrib><creatorcontrib>Tan, Xiaohua</creatorcontrib><creatorcontrib>Xu, Xianrong</creatorcontrib><creatorcontrib>Hong, Yu</creatorcontrib><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><title>Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description>ObjectivesPeripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk.Study designA community-based case–control study.Participants271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China.Outcome measuresPeripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests.ResultsAmong controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p<0.001), but not in those with lower vegetable intake (P-interaction=0.008).ConclusionsCertain dietary factors might modify telomere-related hypertension risk.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Antihypertensives</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Cholesterol</subject><subject>Chronic illnesses</subject><subject>Community</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Food</subject><subject>Gender</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - genetics</subject><subject>Hypertension - prevention & control</subject><subject>Leukocytes</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutrition and Metabolism</subject><subject>Odds Ratio</subject><subject>Oxidative stress</subject><subject>Questionnaires</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Surveys and Questionnaires</subject><subject>Telomerase</subject><subject>Telomere</subject><subject>Telomere Shortening</subject><subject>Thermal cycling</subject><subject>Triglycerides</subject><subject>Vegetables</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc2KFDEUhYMozjDOEwgScOOmxvx3lQtBhvEHBtzoOiSpW13VpJIySY30zqV739AnMWO3w-jKkJCQfOfkXg5CTym5oJSrl3bexQVCwwiVDSEdJ_IBOmVEiEYRKR_eO5-g85x3pA4hOynZY3TClFSEKHGKvl8NA7iC44BvYAvFWA_YxZDXeSlTDLjOMgI2OUc3md9XFspXgIAXSNMyQjIee1hddPsCuICPMySoV2FbRmxCj8d9RQuEXNWvsMHOZPj57Uf9pqTocS5rv3-CHg3GZzg_7mfo89urT5fvm-uP7z5cvrlurFBtaVpmBweCDJy3m44Q67jsVe_YIFhdljBFmHUKaC9bR3vasY1jTnFFjTTU8jP0-uC7rHaG3kGtwXi9pGk2aa-jmfTfL2Ea9TbeaKGkYK2sBi-OBil-WSEXPU_ZgfcmQFyzphvOaSeo6ir6_B90F9cUanuatopWQ055pfiBcinmnGC4K4YSfRu2Poatb8PWh7Cr6tn9Pu40f6KtwMUBqOr_cvwFzQa6YA</recordid><startdate>20151111</startdate><enddate>20151111</enddate><creator>Lian, Fuzhi</creator><creator>Wang, Jinquan</creator><creator>Huang, Xianhong</creator><creator>Wu, Yinyin</creator><creator>Cao, Yifei</creator><creator>Tan, Xiaohua</creator><creator>Xu, Xianrong</creator><creator>Hong, Yu</creator><creator>Yang, Lei</creator><creator>Gao, Xiang</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0733-579X</orcidid></search><sort><creationdate>20151111</creationdate><title>Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study</title><author>Lian, Fuzhi ; Wang, Jinquan ; Huang, Xianhong ; Wu, Yinyin ; Cao, Yifei ; Tan, Xiaohua ; Xu, Xianrong ; Hong, Yu ; Yang, Lei ; Gao, Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b468t-82bfce40f3387900bc35d6dc2f422f4b02602bc6e1d58c1d1927c2c6361a5a1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Antihypertensives</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Cholesterol</topic><topic>Chronic illnesses</topic><topic>Community</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Food</topic><topic>Gender</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - genetics</topic><topic>Hypertension - prevention & control</topic><topic>Leukocytes</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nutrition and Metabolism</topic><topic>Odds Ratio</topic><topic>Oxidative stress</topic><topic>Questionnaires</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Surveys and Questionnaires</topic><topic>Telomerase</topic><topic>Telomere</topic><topic>Telomere Shortening</topic><topic>Thermal cycling</topic><topic>Triglycerides</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lian, Fuzhi</creatorcontrib><creatorcontrib>Wang, Jinquan</creatorcontrib><creatorcontrib>Huang, Xianhong</creatorcontrib><creatorcontrib>Wu, Yinyin</creatorcontrib><creatorcontrib>Cao, Yifei</creatorcontrib><creatorcontrib>Tan, Xiaohua</creatorcontrib><creatorcontrib>Xu, Xianrong</creatorcontrib><creatorcontrib>Hong, Yu</creatorcontrib><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lian, Fuzhi</au><au>Wang, Jinquan</au><au>Huang, Xianhong</au><au>Wu, Yinyin</au><au>Cao, Yifei</au><au>Tan, Xiaohua</au><au>Xu, Xianrong</au><au>Hong, Yu</au><au>Yang, Lei</au><au>Gao, Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study</atitle><jtitle>BMJ open</jtitle><addtitle>BMJ Open</addtitle><date>2015-11-11</date><risdate>2015</risdate><volume>5</volume><issue>11</issue><spage>e009305</spage><epage>e009305</epage><pages>e009305-e009305</pages><issn>2044-6055</issn><eissn>2044-6055</eissn><abstract>ObjectivesPeripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk.Study designA community-based case–control study.Participants271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China.Outcome measuresPeripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests.ResultsAmong controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p<0.001), but not in those with lower vegetable intake (P-interaction=0.008).ConclusionsCertain dietary factors might modify telomere-related hypertension risk.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>26560064</pmid><doi>10.1136/bmjopen-2015-009305</doi><orcidid>https://orcid.org/0000-0002-0733-579X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adult Age Aged Aging - physiology Antihypertensives Blood pressure Body mass index Case-Control Studies China Cholesterol Chronic illnesses Community Diabetes Diet Feeding Behavior Female Food Gender High density lipoprotein Humans Hypertension Hypertension - genetics Hypertension - prevention & control Leukocytes Logistic Models Male Middle Aged Nutrition and Metabolism Odds Ratio Oxidative stress Questionnaires Real-Time Polymerase Chain Reaction Risk Factors Smoking Surveys and Questionnaires Telomerase Telomere Telomere Shortening Thermal cycling Triglycerides Vegetables |
title | Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study |
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