Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice
This study examined the effects of lactosucrose (4G-β-D-galactosylsucrose) on influenza A virus infections in mice. First, the effects of lactosucrose on fermentation in the cecum and on immune function were investigated. In female BALB/c mice, lactosucrose supplementation for 6 weeks promoted cecal...
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Veröffentlicht in: | Bioscience of Microbiota, Food and Health Food and Health, 2015, Vol.34(4), pp.67-76 |
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description | This study examined the effects of lactosucrose (4G-β-D-galactosylsucrose) on influenza A virus infections in mice. First, the effects of lactosucrose on fermentation in the cecum and on immune function were investigated. In female BALB/c mice, lactosucrose supplementation for 6 weeks promoted cecal fermentation and increased both secretory IgA (SIgA) levels in feces and total IgA and IgG2a concentrations in serum. Both the percentage of CD4+ T cells in Peyer’s patches and the cytotoxic activity of splenic natural killer (NK) cells increased significantly in response to lactosucrose. Next, we examined the effects of lactosucrose on low-dose influenza A virus infection in mice. After 2 weeks of dietary supplementation with lactosucrose, the mice were infected with low-dose influenza A virus. At 7 days post infection, a comparison with control mice showed that weight loss was suppressed, as were viral titers in the lungs. In the spleens of lactosucrose-fed mice, there was an increase in the percentage of NK cells. Lastly, mice fed lactosucrose were challenged with a lethal dose of influenza A virus. The survival rate of these mice was significantly higher than that of mice fed a control diet. These results suggested that lactosucrose supplementation suppresses influenza A virus infection by augmenting innate immune responses and enhancing cellular and mucosal immunity. |
doi_str_mv | 10.12938/bmfh.2015-005 |
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First, the effects of lactosucrose on fermentation in the cecum and on immune function were investigated. In female BALB/c mice, lactosucrose supplementation for 6 weeks promoted cecal fermentation and increased both secretory IgA (SIgA) levels in feces and total IgA and IgG2a concentrations in serum. Both the percentage of CD4+ T cells in Peyer’s patches and the cytotoxic activity of splenic natural killer (NK) cells increased significantly in response to lactosucrose. Next, we examined the effects of lactosucrose on low-dose influenza A virus infection in mice. After 2 weeks of dietary supplementation with lactosucrose, the mice were infected with low-dose influenza A virus. At 7 days post infection, a comparison with control mice showed that weight loss was suppressed, as were viral titers in the lungs. In the spleens of lactosucrose-fed mice, there was an increase in the percentage of NK cells. Lastly, mice fed lactosucrose were challenged with a lethal dose of influenza A virus. The survival rate of these mice was significantly higher than that of mice fed a control diet. These results suggested that lactosucrose supplementation suppresses influenza A virus infection by augmenting innate immune responses and enhancing cellular and mucosal immunity.</description><identifier>ISSN: 2186-6953</identifier><identifier>ISSN: 2186-3342</identifier><identifier>EISSN: 2186-3342</identifier><identifier>DOI: 10.12938/bmfh.2015-005</identifier><identifier>PMID: 26594606</identifier><language>eng</language><publisher>Japan: BMFH Press</publisher><subject>cytotoxic activity ; lactosucrose ; mucosal immunity ; secretory IgA ; serum IgA ; splenic NK cells</subject><ispartof>Bioscience of Microbiota, Food and Health, 2015, Vol.34(4), pp.67-76</ispartof><rights>2015 by BMFH Press</rights><rights>BMFH Press 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6205-d757ea8948dbfcb6292d12d1b3179dfdb769415c8cea6660284174b0f95dbebd3</citedby><cites>FETCH-LOGICAL-c6205-d757ea8948dbfcb6292d12d1b3179dfdb769415c8cea6660284174b0f95dbebd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654070/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654070/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1883,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26594606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KISHINO, Eriko</creatorcontrib><creatorcontrib>TAKEMURA, Naho</creatorcontrib><creatorcontrib>MASAKI, Hisaharu</creatorcontrib><creatorcontrib>ITO, Tetsuya</creatorcontrib><creatorcontrib>NAKAZAWA, Masatoshi</creatorcontrib><title>Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice</title><title>Bioscience of Microbiota, Food and Health</title><addtitle>Biosci Microbiota Food Health</addtitle><description>This study examined the effects of lactosucrose (4G-β-D-galactosylsucrose) on influenza A virus infections in mice. First, the effects of lactosucrose on fermentation in the cecum and on immune function were investigated. In female BALB/c mice, lactosucrose supplementation for 6 weeks promoted cecal fermentation and increased both secretory IgA (SIgA) levels in feces and total IgA and IgG2a concentrations in serum. Both the percentage of CD4+ T cells in Peyer’s patches and the cytotoxic activity of splenic natural killer (NK) cells increased significantly in response to lactosucrose. Next, we examined the effects of lactosucrose on low-dose influenza A virus infection in mice. After 2 weeks of dietary supplementation with lactosucrose, the mice were infected with low-dose influenza A virus. At 7 days post infection, a comparison with control mice showed that weight loss was suppressed, as were viral titers in the lungs. In the spleens of lactosucrose-fed mice, there was an increase in the percentage of NK cells. Lastly, mice fed lactosucrose were challenged with a lethal dose of influenza A virus. The survival rate of these mice was significantly higher than that of mice fed a control diet. These results suggested that lactosucrose supplementation suppresses influenza A virus infection by augmenting innate immune responses and enhancing cellular and mucosal immunity.</description><subject>cytotoxic activity</subject><subject>lactosucrose</subject><subject>mucosal immunity</subject><subject>secretory IgA</subject><subject>serum IgA</subject><subject>splenic NK cells</subject><issn>2186-6953</issn><issn>2186-3342</issn><issn>2186-3342</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpVkNtLwzAUxoMobsy9-ih91IfO3Nu-CGNepgx90eeQpKdbRteOpB3oX293RUPIOfB95xfOh9A1wSNCM5bem1WxGFFMRIyxOEN9SlIZM8bp-aGXmWA9NAxhibsjsZCcXaIelSLjEss-ent00Gj_HZXaNnVora8DRKFdrz2EACFyVVG2UP3oaBzdTsk7uYs2zrc7AWzj6qrropWzcIUuCl0GGB7qAH09P31OpvHs4-V1Mp7FVlIs4jwRCeg042luCmskzWhOumsYSbK8yE0iM06ETS1oKSWmKScJN7jIRG7A5GyAHvbcdWtWkFuoGq9LtfZu1S2iau3Uf6VyCzWvN4pLwXGCO8BoD9guGzwUp1mC1S5YtQ1WbYNVXbDdwM3fH0_2Y4ydYbI3LEOj53AyaN84W8Iex7ji2-eIPal2ob2Civ0Cph-NZg</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>KISHINO, Eriko</creator><creator>TAKEMURA, Naho</creator><creator>MASAKI, Hisaharu</creator><creator>ITO, Tetsuya</creator><creator>NAKAZAWA, Masatoshi</creator><general>BMFH Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>2015</creationdate><title>Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice</title><author>KISHINO, Eriko ; TAKEMURA, Naho ; MASAKI, Hisaharu ; ITO, Tetsuya ; NAKAZAWA, Masatoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6205-d757ea8948dbfcb6292d12d1b3179dfdb769415c8cea6660284174b0f95dbebd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>cytotoxic activity</topic><topic>lactosucrose</topic><topic>mucosal immunity</topic><topic>secretory IgA</topic><topic>serum IgA</topic><topic>splenic NK cells</topic><toplevel>online_resources</toplevel><creatorcontrib>KISHINO, Eriko</creatorcontrib><creatorcontrib>TAKEMURA, Naho</creatorcontrib><creatorcontrib>MASAKI, Hisaharu</creatorcontrib><creatorcontrib>ITO, Tetsuya</creatorcontrib><creatorcontrib>NAKAZAWA, Masatoshi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioscience of Microbiota, Food and Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KISHINO, Eriko</au><au>TAKEMURA, Naho</au><au>MASAKI, Hisaharu</au><au>ITO, Tetsuya</au><au>NAKAZAWA, Masatoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice</atitle><jtitle>Bioscience of Microbiota, Food and Health</jtitle><addtitle>Biosci Microbiota Food Health</addtitle><date>2015</date><risdate>2015</risdate><volume>34</volume><issue>4</issue><spage>67</spage><epage>76</epage><pages>67-76</pages><issn>2186-6953</issn><issn>2186-3342</issn><eissn>2186-3342</eissn><abstract>This study examined the effects of lactosucrose (4G-β-D-galactosylsucrose) on influenza A virus infections in mice. First, the effects of lactosucrose on fermentation in the cecum and on immune function were investigated. In female BALB/c mice, lactosucrose supplementation for 6 weeks promoted cecal fermentation and increased both secretory IgA (SIgA) levels in feces and total IgA and IgG2a concentrations in serum. Both the percentage of CD4+ T cells in Peyer’s patches and the cytotoxic activity of splenic natural killer (NK) cells increased significantly in response to lactosucrose. Next, we examined the effects of lactosucrose on low-dose influenza A virus infection in mice. After 2 weeks of dietary supplementation with lactosucrose, the mice were infected with low-dose influenza A virus. At 7 days post infection, a comparison with control mice showed that weight loss was suppressed, as were viral titers in the lungs. In the spleens of lactosucrose-fed mice, there was an increase in the percentage of NK cells. Lastly, mice fed lactosucrose were challenged with a lethal dose of influenza A virus. The survival rate of these mice was significantly higher than that of mice fed a control diet. These results suggested that lactosucrose supplementation suppresses influenza A virus infection by augmenting innate immune responses and enhancing cellular and mucosal immunity.</abstract><cop>Japan</cop><pub>BMFH Press</pub><pmid>26594606</pmid><doi>10.12938/bmfh.2015-005</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | cytotoxic activity lactosucrose mucosal immunity secretory IgA serum IgA splenic NK cells |
title | Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice |
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