The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation
Using radiobiological modelling to estimate normal tissue toxicity, this study investigates the effects of dose escalation for concurrent chemoradiation therapy (CRT) in lower third oesophageal tumours on the stomach. 10 patients with lower third oesophageal cancer were selected from the SCOPE 1 dat...
Gespeichert in:
| Veröffentlicht in: | Radiation oncology (London, England) England), 2015-11, Vol.10 (234), p.236, Article 236 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 234 |
| container_start_page | 236 |
| container_title | Radiation oncology (London, England) |
| container_volume | 10 |
| creator | Carrington, Rhys Staffurth, John Warren, Samantha Partridge, Mike Hurt, Chris Spezi, Emiliano Gwynne, Sarah Hawkins, Maria A Crosby, Thomas |
| description | Using radiobiological modelling to estimate normal tissue toxicity, this study investigates the effects of dose escalation for concurrent chemoradiation therapy (CRT) in lower third oesophageal tumours on the stomach.
10 patients with lower third oesophageal cancer were selected from the SCOPE 1 database (ISCRT47718479) with a mean planning target volume (PTV) of 348 cm(3). The original 3D conformal plans (50 Gy3D) were compared to newly created RapidArc plans of 50 GyRA and 60 GyRA, the latter using a simultaneous integrated boost (SIB) technique using a boost volume, PTV2. Dose-volume metrics and estimates of normal tissue complication probability (NTCP) were compared.
There was a significant increase in NTCP of the stomach wall when moving from the 50 GyRA to the 60 GyRA plans (11-17 %, Wilcoxon signed rank test, p = 0.01). There was a strong correlation between the NTCP values of the stomach wall and the volume of the stomach wall/PTV 1 and stomach wall/PTV2 overlap structures (R = 0.80 and R = 0.82 respectively) for the 60 GyRA plans.
Radiobiological modelling suggests that increasing the prescribed dose to 60 Gy may be associated with a significantly increased risk of toxicity to the stomach. It is recommended that stomach toxicity be closely monitored when treating patients with lower third oesophageal tumours with 60 Gy. |
| doi_str_mv | 10.1186/s13014-015-0537-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4653919</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A449506225</galeid><sourcerecordid>A449506225</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-4fbbdebf071e5816b719e73044362d95bad3836e1566cffef2a776816abbf0e33</originalsourceid><addsrcrecordid>eNptUttqFTEUHUSxF_0AXyTg89Rkcpv4IJSiVSj0pYW-hUxmZ07KTHJMctoev97UU3sByYbc1lrsxV5N84HgI0J68TkTiglrMeEt5lS221fNPpGsbyWRV6-fnfeag5yvMWacYvW22esE7wWVfL_5fbECBM6BLSg6NMZcr9ma2RQfA6o1mVySt6jEO2992aLbFQRUElREmNAcbyGhCDmuV2YCM6OyWeIm5S_IoGRGHwcf5zj5qol8uIFc_PRX_F3zxpk5w_uH_bC5_P7t4uRHe3Z--vPk-Ky1TLHSMjcMIwwOSwK8J2KQRIGkmDEqulHxwYy0pwIIF8JWI64zUooKNEMlAaWHzded7nozLDBaCCWZWa-TX0za6mi8fvkT_EpP8UYzwakiqgp8ehBI8demGtDX1WCoPWsipZK9xIo-oSYzg_bBxSpmF5-tPmZMcSy6jlfU0X9QdY2weBsDOF_fXxDIjmBTzDmBe2ycYH2fAr1Lga4p0Pcp0NvK-fjc8SPj39jpHymQsMk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779787093</pqid></control><display><type>article</type><title>The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation</title><source>SpringerOpen</source><source>MEDLINE</source><source>PMC (PubMed Central)</source><source>SpringerLink Journals (MCLS)</source><source>DOAJ Directory of Open Access Journals</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Carrington, Rhys ; Staffurth, John ; Warren, Samantha ; Partridge, Mike ; Hurt, Chris ; Spezi, Emiliano ; Gwynne, Sarah ; Hawkins, Maria A ; Crosby, Thomas</creator><creatorcontrib>Carrington, Rhys ; Staffurth, John ; Warren, Samantha ; Partridge, Mike ; Hurt, Chris ; Spezi, Emiliano ; Gwynne, Sarah ; Hawkins, Maria A ; Crosby, Thomas</creatorcontrib><description>Using radiobiological modelling to estimate normal tissue toxicity, this study investigates the effects of dose escalation for concurrent chemoradiation therapy (CRT) in lower third oesophageal tumours on the stomach.
10 patients with lower third oesophageal cancer were selected from the SCOPE 1 database (ISCRT47718479) with a mean planning target volume (PTV) of 348 cm(3). The original 3D conformal plans (50 Gy3D) were compared to newly created RapidArc plans of 50 GyRA and 60 GyRA, the latter using a simultaneous integrated boost (SIB) technique using a boost volume, PTV2. Dose-volume metrics and estimates of normal tissue complication probability (NTCP) were compared.
There was a significant increase in NTCP of the stomach wall when moving from the 50 GyRA to the 60 GyRA plans (11-17 %, Wilcoxon signed rank test, p = 0.01). There was a strong correlation between the NTCP values of the stomach wall and the volume of the stomach wall/PTV 1 and stomach wall/PTV2 overlap structures (R = 0.80 and R = 0.82 respectively) for the 60 GyRA plans.
Radiobiological modelling suggests that increasing the prescribed dose to 60 Gy may be associated with a significantly increased risk of toxicity to the stomach. It is recommended that stomach toxicity be closely monitored when treating patients with lower third oesophageal tumours with 60 Gy.</description><identifier>ISSN: 1748-717X</identifier><identifier>EISSN: 1748-717X</identifier><identifier>DOI: 10.1186/s13014-015-0537-y</identifier><identifier>PMID: 26586375</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Cancer ; Carcinoma ; Care and treatment ; Complications and side effects ; Development and progression ; Esophageal Neoplasms - radiotherapy ; Health aspects ; Humans ; Models, Theoretical ; Organs at Risk - radiation effects ; Radiation Injuries - prevention & control ; Radiotherapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Conformal - methods ; Stomach - radiation effects</subject><ispartof>Radiation oncology (London, England), 2015-11, Vol.10 (234), p.236, Article 236</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Carrington et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-4fbbdebf071e5816b719e73044362d95bad3836e1566cffef2a776816abbf0e33</citedby><cites>FETCH-LOGICAL-c494t-4fbbdebf071e5816b719e73044362d95bad3836e1566cffef2a776816abbf0e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653919/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653919/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26586375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carrington, Rhys</creatorcontrib><creatorcontrib>Staffurth, John</creatorcontrib><creatorcontrib>Warren, Samantha</creatorcontrib><creatorcontrib>Partridge, Mike</creatorcontrib><creatorcontrib>Hurt, Chris</creatorcontrib><creatorcontrib>Spezi, Emiliano</creatorcontrib><creatorcontrib>Gwynne, Sarah</creatorcontrib><creatorcontrib>Hawkins, Maria A</creatorcontrib><creatorcontrib>Crosby, Thomas</creatorcontrib><title>The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation</title><title>Radiation oncology (London, England)</title><addtitle>Radiat Oncol</addtitle><description>Using radiobiological modelling to estimate normal tissue toxicity, this study investigates the effects of dose escalation for concurrent chemoradiation therapy (CRT) in lower third oesophageal tumours on the stomach.
10 patients with lower third oesophageal cancer were selected from the SCOPE 1 database (ISCRT47718479) with a mean planning target volume (PTV) of 348 cm(3). The original 3D conformal plans (50 Gy3D) were compared to newly created RapidArc plans of 50 GyRA and 60 GyRA, the latter using a simultaneous integrated boost (SIB) technique using a boost volume, PTV2. Dose-volume metrics and estimates of normal tissue complication probability (NTCP) were compared.
There was a significant increase in NTCP of the stomach wall when moving from the 50 GyRA to the 60 GyRA plans (11-17 %, Wilcoxon signed rank test, p = 0.01). There was a strong correlation between the NTCP values of the stomach wall and the volume of the stomach wall/PTV 1 and stomach wall/PTV2 overlap structures (R = 0.80 and R = 0.82 respectively) for the 60 GyRA plans.
Radiobiological modelling suggests that increasing the prescribed dose to 60 Gy may be associated with a significantly increased risk of toxicity to the stomach. It is recommended that stomach toxicity be closely monitored when treating patients with lower third oesophageal tumours with 60 Gy.</description><subject>Cancer</subject><subject>Carcinoma</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Esophageal Neoplasms - radiotherapy</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Models, Theoretical</subject><subject>Organs at Risk - radiation effects</subject><subject>Radiation Injuries - prevention & control</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Radiotherapy, Conformal - methods</subject><subject>Stomach - radiation effects</subject><issn>1748-717X</issn><issn>1748-717X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUttqFTEUHUSxF_0AXyTg89Rkcpv4IJSiVSj0pYW-hUxmZ07KTHJMctoev97UU3sByYbc1lrsxV5N84HgI0J68TkTiglrMeEt5lS221fNPpGsbyWRV6-fnfeag5yvMWacYvW22esE7wWVfL_5fbECBM6BLSg6NMZcr9ma2RQfA6o1mVySt6jEO2992aLbFQRUElREmNAcbyGhCDmuV2YCM6OyWeIm5S_IoGRGHwcf5zj5qol8uIFc_PRX_F3zxpk5w_uH_bC5_P7t4uRHe3Z--vPk-Ky1TLHSMjcMIwwOSwK8J2KQRIGkmDEqulHxwYy0pwIIF8JWI64zUooKNEMlAaWHzded7nozLDBaCCWZWa-TX0za6mi8fvkT_EpP8UYzwakiqgp8ehBI8demGtDX1WCoPWsipZK9xIo-oSYzg_bBxSpmF5-tPmZMcSy6jlfU0X9QdY2weBsDOF_fXxDIjmBTzDmBe2ycYH2fAr1Lga4p0Pcp0NvK-fjc8SPj39jpHymQsMk</recordid><startdate>20151119</startdate><enddate>20151119</enddate><creator>Carrington, Rhys</creator><creator>Staffurth, John</creator><creator>Warren, Samantha</creator><creator>Partridge, Mike</creator><creator>Hurt, Chris</creator><creator>Spezi, Emiliano</creator><creator>Gwynne, Sarah</creator><creator>Hawkins, Maria A</creator><creator>Crosby, Thomas</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20151119</creationdate><title>The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation</title><author>Carrington, Rhys ; Staffurth, John ; Warren, Samantha ; Partridge, Mike ; Hurt, Chris ; Spezi, Emiliano ; Gwynne, Sarah ; Hawkins, Maria A ; Crosby, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-4fbbdebf071e5816b719e73044362d95bad3836e1566cffef2a776816abbf0e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Cancer</topic><topic>Carcinoma</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Esophageal Neoplasms - radiotherapy</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Models, Theoretical</topic><topic>Organs at Risk - radiation effects</topic><topic>Radiation Injuries - prevention & control</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Radiotherapy, Conformal - methods</topic><topic>Stomach - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrington, Rhys</creatorcontrib><creatorcontrib>Staffurth, John</creatorcontrib><creatorcontrib>Warren, Samantha</creatorcontrib><creatorcontrib>Partridge, Mike</creatorcontrib><creatorcontrib>Hurt, Chris</creatorcontrib><creatorcontrib>Spezi, Emiliano</creatorcontrib><creatorcontrib>Gwynne, Sarah</creatorcontrib><creatorcontrib>Hawkins, Maria A</creatorcontrib><creatorcontrib>Crosby, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Radiation oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrington, Rhys</au><au>Staffurth, John</au><au>Warren, Samantha</au><au>Partridge, Mike</au><au>Hurt, Chris</au><au>Spezi, Emiliano</au><au>Gwynne, Sarah</au><au>Hawkins, Maria A</au><au>Crosby, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation</atitle><jtitle>Radiation oncology (London, England)</jtitle><addtitle>Radiat Oncol</addtitle><date>2015-11-19</date><risdate>2015</risdate><volume>10</volume><issue>234</issue><spage>236</spage><pages>236-</pages><artnum>236</artnum><issn>1748-717X</issn><eissn>1748-717X</eissn><abstract>Using radiobiological modelling to estimate normal tissue toxicity, this study investigates the effects of dose escalation for concurrent chemoradiation therapy (CRT) in lower third oesophageal tumours on the stomach.
10 patients with lower third oesophageal cancer were selected from the SCOPE 1 database (ISCRT47718479) with a mean planning target volume (PTV) of 348 cm(3). The original 3D conformal plans (50 Gy3D) were compared to newly created RapidArc plans of 50 GyRA and 60 GyRA, the latter using a simultaneous integrated boost (SIB) technique using a boost volume, PTV2. Dose-volume metrics and estimates of normal tissue complication probability (NTCP) were compared.
There was a significant increase in NTCP of the stomach wall when moving from the 50 GyRA to the 60 GyRA plans (11-17 %, Wilcoxon signed rank test, p = 0.01). There was a strong correlation between the NTCP values of the stomach wall and the volume of the stomach wall/PTV 1 and stomach wall/PTV2 overlap structures (R = 0.80 and R = 0.82 respectively) for the 60 GyRA plans.
Radiobiological modelling suggests that increasing the prescribed dose to 60 Gy may be associated with a significantly increased risk of toxicity to the stomach. It is recommended that stomach toxicity be closely monitored when treating patients with lower third oesophageal tumours with 60 Gy.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26586375</pmid><doi>10.1186/s13014-015-0537-y</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1748-717X |
| ispartof | Radiation oncology (London, England), 2015-11, Vol.10 (234), p.236, Article 236 |
| issn | 1748-717X 1748-717X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4653919 |
| source | SpringerOpen; MEDLINE; PMC (PubMed Central); SpringerLink Journals (MCLS); DOAJ Directory of Open Access Journals; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Cancer Carcinoma Care and treatment Complications and side effects Development and progression Esophageal Neoplasms - radiotherapy Health aspects Humans Models, Theoretical Organs at Risk - radiation effects Radiation Injuries - prevention & control Radiotherapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Conformal - methods Stomach - radiation effects |
| title | The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T16%3A18%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20dose%20escalation%20on%20gastric%20toxicity%20when%20treating%20lower%20oesophageal%20tumours:%20a%20radiobiological%20investigation&rft.jtitle=Radiation%20oncology%20(London,%20England)&rft.au=Carrington,%20Rhys&rft.date=2015-11-19&rft.volume=10&rft.issue=234&rft.spage=236&rft.pages=236-&rft.artnum=236&rft.issn=1748-717X&rft.eissn=1748-717X&rft_id=info:doi/10.1186/s13014-015-0537-y&rft_dat=%3Cgale_pubme%3EA449506225%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1779787093&rft_id=info:pmid/26586375&rft_galeid=A449506225&rfr_iscdi=true |