MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance

Establishing a diagnosis in patients suspected of having a myelodysplastic syndrome (MDS) can be challenging and could be informed by the identification of somatic mutations. We performed a prospective study to examine the frequency and types of mutations encountered in 144 patients with unexplained...

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Veröffentlicht in:	Blood 2015-11, Vol.126 (21), p.2355-2361
Hauptverfasser:	Kwok, Brian, Hall, Jeff M., Witte, John S., Xu, Yin, Reddy, Prashanti, Lin, Keming, Flamholz, Rachel, Dabbas, Bashar, Yung, Aine, Al-Hafidh, Jenan, Balmert, Emily, Vaupel, Christine, El Hader, Carlos, McGinniss, Matthew J., Nahas, Shareef A., Kines, Julie, Bejar, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alleles Chromosome Aberrations Female Gene Frequency Hematopoiesis - genetics Humans Male Mutation Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology Plenary Paper Prospective Studies Retrospective Studies
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