genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population
Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6 PUFAs in primarily subjects of European ancestry. However, the relevance of these findings...
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| Veröffentlicht in: | Genes & nutrition 2015-11, Vol.10 (6), p.53-53, Article 53 |
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| creator | Dorajoo, Rajkumar Sun, Ye Han, Yi Ke, Tingjing Burger, Ayala Chang, Xuling Low, Hui Qi Guan, Weihua Lemaitre, Rozenn N Khor, Chiea-Chuen Yuan, Jian-Min Koh, Woon-Puay Ong, Choon Nam Tai, E Shyong Liu, Jianjun van Dam, Rob M Heng, Chew-Kiat Friedlander, Yechiel |
| description | Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6 PUFAs in primarily subjects of European ancestry. However, the relevance of these findings has not been evaluated extensively in other ethnic groups. The primary aim of this study was to evaluate for genetic loci associated with n-3 and n-6 PUFAs and to validate the role of recently identified index loci using data from a Singaporean Chinese population. Using a GWAS approach, we evaluated associations with plasma concentrations of three n-3 PUFAs [alphalinolenic acid (ALA), eicosapentaenoic acid and docosahexaenoic acid], four n-6 PUFAs [linoleic acid (LA), gammalinolenic acid, dihomogammalinolenic acid (DGLA) and arachidonic acid], and estimates of delta-5 desaturase and delta-6 desaturase activities among the participants (N = 1361) of the Singaporean Chinese Health Study. Our results reveal robust genome-wide associations (p value |
| doi_str_mv | 10.1007/s12263-015-0502-2 |
| format | Article |
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Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6 PUFAs in primarily subjects of European ancestry. However, the relevance of these findings has not been evaluated extensively in other ethnic groups. The primary aim of this study was to evaluate for genetic loci associated with n-3 and n-6 PUFAs and to validate the role of recently identified index loci using data from a Singaporean Chinese population. Using a GWAS approach, we evaluated associations with plasma concentrations of three n-3 PUFAs [alphalinolenic acid (ALA), eicosapentaenoic acid and docosahexaenoic acid], four n-6 PUFAs [linoleic acid (LA), gammalinolenic acid, dihomogammalinolenic acid (DGLA) and arachidonic acid], and estimates of delta-5 desaturase and delta-6 desaturase activities among the participants (N = 1361) of the Singaporean Chinese Health Study. Our results reveal robust genome-wide associations (p value <5 × 10⁻⁸) with ALA, all four n-6 PUFAs, and delta-6 desaturase activity at the FADS1/FADS2 locus. We further replicated the associations between common index variants at the NTAN1/PDXDC1 locus and n-6 PUFAs LA and DGLA, and between the JMJD1C locus and n-6 PUFA LA (p value between 0.0490 and 9.88 × 10⁻⁴). These associations were independent of dietary intake of PUFAs. In aggregate, we show that genetic loci that influence plasma concentrations of n-3 and n-6 PUFAs are shared across different ethnic groups.</description><identifier>ISSN: 1555-8932</identifier><identifier>EISSN: 1865-3499</identifier><identifier>DOI: 10.1007/s12263-015-0502-2</identifier><identifier>PMID: 26584805</identifier><language>eng</language><publisher>Germany: Springer Berlin Heidelberg</publisher><subject>ancestry ; arachidonic acid ; docosahexaenoic acid ; eicosapentaenoic acid ; food intake ; genome-wide association study ; human health ; linoleic acid ; loci ; nationalities and ethnic groups ; omega-3 fatty acids ; omega-6 fatty acids ; Research Paper</subject><ispartof>Genes & nutrition, 2015-11, Vol.10 (6), p.53-53, Article 53</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-e6ecac8e61629226370bbc63c3a8d885790ac4b4834a266b95e0c9d5e87f14bc3</citedby><cites>FETCH-LOGICAL-c522t-e6ecac8e61629226370bbc63c3a8d885790ac4b4834a266b95e0c9d5e87f14bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653118/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653118/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26584805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dorajoo, Rajkumar</creatorcontrib><creatorcontrib>Sun, Ye</creatorcontrib><creatorcontrib>Han, Yi</creatorcontrib><creatorcontrib>Ke, Tingjing</creatorcontrib><creatorcontrib>Burger, Ayala</creatorcontrib><creatorcontrib>Chang, Xuling</creatorcontrib><creatorcontrib>Low, Hui Qi</creatorcontrib><creatorcontrib>Guan, Weihua</creatorcontrib><creatorcontrib>Lemaitre, Rozenn N</creatorcontrib><creatorcontrib>Khor, Chiea-Chuen</creatorcontrib><creatorcontrib>Yuan, Jian-Min</creatorcontrib><creatorcontrib>Koh, Woon-Puay</creatorcontrib><creatorcontrib>Ong, Choon Nam</creatorcontrib><creatorcontrib>Tai, E Shyong</creatorcontrib><creatorcontrib>Liu, Jianjun</creatorcontrib><creatorcontrib>van Dam, Rob M</creatorcontrib><creatorcontrib>Heng, Chew-Kiat</creatorcontrib><creatorcontrib>Friedlander, Yechiel</creatorcontrib><title>genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population</title><title>Genes & nutrition</title><addtitle>Genes Nutr</addtitle><description>Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6 PUFAs in primarily subjects of European ancestry. However, the relevance of these findings has not been evaluated extensively in other ethnic groups. The primary aim of this study was to evaluate for genetic loci associated with n-3 and n-6 PUFAs and to validate the role of recently identified index loci using data from a Singaporean Chinese population. Using a GWAS approach, we evaluated associations with plasma concentrations of three n-3 PUFAs [alphalinolenic acid (ALA), eicosapentaenoic acid and docosahexaenoic acid], four n-6 PUFAs [linoleic acid (LA), gammalinolenic acid, dihomogammalinolenic acid (DGLA) and arachidonic acid], and estimates of delta-5 desaturase and delta-6 desaturase activities among the participants (N = 1361) of the Singaporean Chinese Health Study. Our results reveal robust genome-wide associations (p value <5 × 10⁻⁸) with ALA, all four n-6 PUFAs, and delta-6 desaturase activity at the FADS1/FADS2 locus. We further replicated the associations between common index variants at the NTAN1/PDXDC1 locus and n-6 PUFAs LA and DGLA, and between the JMJD1C locus and n-6 PUFA LA (p value between 0.0490 and 9.88 × 10⁻⁴). These associations were independent of dietary intake of PUFAs. In aggregate, we show that genetic loci that influence plasma concentrations of n-3 and n-6 PUFAs are shared across different ethnic groups.</description><subject>ancestry</subject><subject>arachidonic acid</subject><subject>docosahexaenoic acid</subject><subject>eicosapentaenoic acid</subject><subject>food intake</subject><subject>genome-wide association study</subject><subject>human health</subject><subject>linoleic acid</subject><subject>loci</subject><subject>nationalities and ethnic groups</subject><subject>omega-3 fatty acids</subject><subject>omega-6 fatty acids</subject><subject>Research Paper</subject><issn>1555-8932</issn><issn>1865-3499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0Eoh_wA7iAj1wM48_YFyS0goJUiUPp2Zo4ztYosUOcgPbfk2VLBSdOM9I882pGDyEvOLzhAM3byoUwkgHXDDQIJh6Rc26NZlI593jrtdbMOinOyEWt3wC0kxKekjNhtFUW9DkJ-5jLGNnP1EWKtZaQcEkl07qs3YGWnmYmKeZuq4ZOA9YRaY_LcqAYUldpyhTpTcp7nMocMdPdXcqxRjqVaR1-Zz0jT3ocanx-Xy_J7ccPX3ef2PWXq8-799csaCEWFk0MGGw03Ah3fKyBtg1GBom2s1Y3DjCoVlmpUBjTOh0huE5H2_RctUFeknen3Gltx9iFmJcZBz_NacT54Asm_-8kpzu_Lz-8MlpybreA1_cBc_m-xrr4MdUQhwFzLGv13IIE23DX_B9tlNOu4aA2lJ_QMJda59g_XMTBHz36k0e_efRHj15sOy__fuVh44-4DXh1AnosHvdzqv72RgA3AFwZLo38BVhpolk</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Dorajoo, Rajkumar</creator><creator>Sun, Ye</creator><creator>Han, Yi</creator><creator>Ke, Tingjing</creator><creator>Burger, Ayala</creator><creator>Chang, Xuling</creator><creator>Low, Hui Qi</creator><creator>Guan, Weihua</creator><creator>Lemaitre, Rozenn N</creator><creator>Khor, Chiea-Chuen</creator><creator>Yuan, Jian-Min</creator><creator>Koh, Woon-Puay</creator><creator>Ong, Choon Nam</creator><creator>Tai, E Shyong</creator><creator>Liu, Jianjun</creator><creator>van Dam, Rob M</creator><creator>Heng, Chew-Kiat</creator><creator>Friedlander, Yechiel</creator><general>Springer Berlin Heidelberg</general><scope>FBQ</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20151101</creationdate><title>genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population</title><author>Dorajoo, Rajkumar ; Sun, Ye ; Han, Yi ; Ke, Tingjing ; Burger, Ayala ; Chang, Xuling ; Low, Hui Qi ; Guan, Weihua ; Lemaitre, Rozenn N ; Khor, Chiea-Chuen ; Yuan, Jian-Min ; Koh, Woon-Puay ; Ong, Choon Nam ; Tai, E Shyong ; Liu, Jianjun ; van Dam, Rob M ; Heng, Chew-Kiat ; Friedlander, Yechiel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-e6ecac8e61629226370bbc63c3a8d885790ac4b4834a266b95e0c9d5e87f14bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>ancestry</topic><topic>arachidonic acid</topic><topic>docosahexaenoic acid</topic><topic>eicosapentaenoic acid</topic><topic>food intake</topic><topic>genome-wide association study</topic><topic>human health</topic><topic>linoleic acid</topic><topic>loci</topic><topic>nationalities and ethnic groups</topic><topic>omega-3 fatty acids</topic><topic>omega-6 fatty acids</topic><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dorajoo, Rajkumar</creatorcontrib><creatorcontrib>Sun, Ye</creatorcontrib><creatorcontrib>Han, Yi</creatorcontrib><creatorcontrib>Ke, Tingjing</creatorcontrib><creatorcontrib>Burger, Ayala</creatorcontrib><creatorcontrib>Chang, Xuling</creatorcontrib><creatorcontrib>Low, Hui Qi</creatorcontrib><creatorcontrib>Guan, Weihua</creatorcontrib><creatorcontrib>Lemaitre, Rozenn N</creatorcontrib><creatorcontrib>Khor, Chiea-Chuen</creatorcontrib><creatorcontrib>Yuan, Jian-Min</creatorcontrib><creatorcontrib>Koh, Woon-Puay</creatorcontrib><creatorcontrib>Ong, Choon Nam</creatorcontrib><creatorcontrib>Tai, E Shyong</creatorcontrib><creatorcontrib>Liu, Jianjun</creatorcontrib><creatorcontrib>van Dam, Rob M</creatorcontrib><creatorcontrib>Heng, Chew-Kiat</creatorcontrib><creatorcontrib>Friedlander, Yechiel</creatorcontrib><collection>AGRIS</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dorajoo, Rajkumar</au><au>Sun, Ye</au><au>Han, Yi</au><au>Ke, Tingjing</au><au>Burger, Ayala</au><au>Chang, Xuling</au><au>Low, Hui Qi</au><au>Guan, Weihua</au><au>Lemaitre, Rozenn N</au><au>Khor, Chiea-Chuen</au><au>Yuan, Jian-Min</au><au>Koh, Woon-Puay</au><au>Ong, Choon Nam</au><au>Tai, E Shyong</au><au>Liu, Jianjun</au><au>van Dam, Rob M</au><au>Heng, Chew-Kiat</au><au>Friedlander, Yechiel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population</atitle><jtitle>Genes & nutrition</jtitle><addtitle>Genes Nutr</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>53</spage><epage>53</epage><pages>53-53</pages><artnum>53</artnum><issn>1555-8932</issn><eissn>1865-3499</eissn><abstract>Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6 PUFAs in primarily subjects of European ancestry. However, the relevance of these findings has not been evaluated extensively in other ethnic groups. The primary aim of this study was to evaluate for genetic loci associated with n-3 and n-6 PUFAs and to validate the role of recently identified index loci using data from a Singaporean Chinese population. Using a GWAS approach, we evaluated associations with plasma concentrations of three n-3 PUFAs [alphalinolenic acid (ALA), eicosapentaenoic acid and docosahexaenoic acid], four n-6 PUFAs [linoleic acid (LA), gammalinolenic acid, dihomogammalinolenic acid (DGLA) and arachidonic acid], and estimates of delta-5 desaturase and delta-6 desaturase activities among the participants (N = 1361) of the Singaporean Chinese Health Study. Our results reveal robust genome-wide associations (p value <5 × 10⁻⁸) with ALA, all four n-6 PUFAs, and delta-6 desaturase activity at the FADS1/FADS2 locus. We further replicated the associations between common index variants at the NTAN1/PDXDC1 locus and n-6 PUFAs LA and DGLA, and between the JMJD1C locus and n-6 PUFA LA (p value between 0.0490 and 9.88 × 10⁻⁴). These associations were independent of dietary intake of PUFAs. In aggregate, we show that genetic loci that influence plasma concentrations of n-3 and n-6 PUFAs are shared across different ethnic groups.</abstract><cop>Germany</cop><pub>Springer Berlin Heidelberg</pub><pmid>26584805</pmid><doi>10.1007/s12263-015-0502-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ancestry arachidonic acid docosahexaenoic acid eicosapentaenoic acid food intake genome-wide association study human health linoleic acid loci nationalities and ethnic groups omega-3 fatty acids omega-6 fatty acids Research Paper |
| title | genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population |
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