Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation

Clinical trials have established the benefit of androgen deprivation therapy (ADT) combined with radiotherapy in prostate cancer. ADT sensitizes prostate cancer to radiotherapy-induced death at least in part through inhibition of DNA repair machinery, but for unknown reasons, adjuvant ADT provides f...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-11, Vol.75 (22), p.4688-4696
Hauptverfasser:	Spratt, Daniel E, Evans, Michael J, Davis, Brian J, Doran, Michael G, Lee, Man Xia, Shah, Neel, Wongvipat, John, Carnazza, Kathryn E, Klee, George G, Polkinghorn, William, Tindall, Donald J, Lewis, Jason S, Sawyers, Charles L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Line, Tumor Comet Assay Fluorescent Antibody Technique Humans Luminescent Measurements Male Mice Mice, SCID Prostatic Neoplasms - metabolism Prostatic Neoplasms - radiotherapy Radiation Tolerance - physiology Real-Time Polymerase Chain Reaction Receptors, Androgen - biosynthesis Up-Regulation Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
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