Activity after Site-Directed Mutagenesis of CD59 on Complement-Mediated Cytolysis

CD59 may inhibit the cytolytic activity of complement by binding to C8/C9 and protect host cell membranes against homologous membrane attack complex （MAC）. However, CD59 is widely overexpressed on tumor cells, which has been implicated in tumorigenesis. The active site of CD59 relative to MAC is sti...

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Veröffentlicht in:	Cellular & molecular immunology 2008-04, Vol.5 (2), p.141-146
Hauptverfasser:	Zhu, Xinhong, Gao, Meihua, Ren, Shurong, Wang, Qiubo, Lin, Cunzhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biomedical and Life Sciences Biomedicine CD59 CD59 antigen CD59 Antigens - genetics CD59 Antigens - metabolism Cell membranes CHO Cells Complement system Complement System Proteins - immunology Cricetinae Cricetulus Cytolysis Cytolytic activity Cytotoxicity, Immunologic - genetics Enzyme-Linked Immunosorbent Assay Gene Expression Regulation Genetic Vectors Humans Hydrophobicity Immunology In Situ Hybridization Medical Microbiology Membrane attack complex Microbiology Mutagenesis Mutagenesis, Site-Directed Mutants RNA, Messenger - metabolism Site-directed mutagenesis Transfection Tumor cells Tumorigenesis Vaccine 基因突变细胞活性
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