DNMT1 mediates chemosensitivity by reducing methylation of miRNA-20a promoter in glioma cells

Although methyltransferase has been recognized as a major element that governs the epigenetic regulation of the genome during temozolomide (TMZ) chemotherapy in glioblastoma multiforme (GBM) patients, its regulatory effect on glioblastoma chemoresistance has not been well defined. This study investi...

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Veröffentlicht in:	Experimental & molecular medicine 2015-09, Vol.47 (9), p.e182-e182
Hauptverfasser:	Zhou, Daoyang, Wan, Yingfeng, Xie, Dajiang, Wang, Yirong, Wei, Junhua, Yan, Qingfeng, Lu, Peng, Mo, Lianjie, Xie, Jixi, Yang, Shuxu, Qi, Xuchen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378 96 Animals Antineoplastic Agents, Alkylating - pharmacology Antineoplastic Agents, Alkylating - therapeutic use Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Brain - pathology Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Dacarbazine - therapeutic use DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation Drug Resistance, Neoplasm Female Gene Expression Regulation, Neoplastic Glioma - drug therapy Glioma - genetics Glioma - pathology Humans Medical Biochemistry Mice, Inbred C57BL MicroRNAs - genetics Molecular Medicine Original original-article Promoter Regions, Genetic Stem Cells Temozolomide
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