Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet

It remains to be established if, and to what extent, the coronary microcirculation becomes compromised during the development of obesity and insulin resistance. Recent studies suggest that changes in endothelial glycocalyx properties contribute to microvascular dysfunction under (pre-)diabetic condi...

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Veröffentlicht in:	Cardiovascular Diabetology 2015-11, Vol.14 (1), p.150-150, Article 150
Hauptverfasser:	van Haare, Judith, Kooi, M Eline, Vink, Hans, Post, Mark J, van Teeffelen, Jurgen W G E, Slenter, Jos, Munts, Chantal, Cobelens, Hanneke, Strijkers, Gustav J, Koehn, Dennis, van Bilsen, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - administration & dosage Analysis Animals Coronary Circulation Coronary Disease - diagnosis Coronary Disease - etiology Coronary Disease - metabolism Coronary Disease - physiopathology Coronary Vessels - metabolism Coronary Vessels - physiopathology Diet, High-Fat Disease Models, Animal Glycocalyx - metabolism Health aspects Hyperemia - physiopathology Insulin Resistance Magnetic Resonance Imaging, Cine Male Microcirculation Microvessels - physiopathology Muscle, Skeletal - blood supply Muscle, Skeletal - metabolism Muscles Myocardial Perfusion Imaging - methods Myocardium - metabolism Obesity Obesity, Abdominal - diagnosis Obesity, Abdominal - etiology Obesity, Abdominal - metabolism Obesity, Abdominal - physiopathology Original Investigation Phosphorylation Prediabetic State - diagnosis Prediabetic State - etiology Prediabetic State - metabolism Prediabetic State - physiopathology Proto-Oncogene Proteins c-akt - metabolism Rats, Wistar Risk factors Time Factors Vasodilator Agents - administration & dosage Ventricular Remodeling
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