Preparation by alkaline treatment and detailed characterisation of empty hepatitis B virus core particles for vaccine and gene therapy applications

Hepatitis B virus (HBV) core (HBc) virus-like particles (VLPs) are one of the most powerful protein engineering tools utilised to expose immunological epitopes and/or cell-targeting signals and for the packaging of genetic material and immune stimulatory sequences. Although HBc VLPs and their numero...

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Veröffentlicht in:	Scientific reports 2015-06, Vol.5 (1), p.11639-11639, Article 11639
Hauptverfasser:	Strods, Arnis, Ose, Velta, Bogans, Janis, Cielens, Indulis, Kalnins, Gints, Radovica, Ilze, Kazaks, Andris, Pumpens, Paul, Renhofa, Regina
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/337/475 639/638/92/612/1256 639/925/352/152 82/29 82/83 Alkalies - chemistry Amino Acid Sequence Core particles Deoxyribonucleic acid DNA Electrophoresis, Polyacrylamide Gel Epitopes Gene therapy Genetic Therapy - methods Glutamic acid Hepatitis Hepatitis B Hepatitis B Core Antigens - genetics Hepatitis B Core Antigens - immunology Hepatitis B Core Antigens - metabolism Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B virus - metabolism Humanities and Social Sciences Hydrogen-Ion Concentration Hydrolysis Lysine Microscopy, Electron Molecular Sequence Data multidisciplinary Mutation Nucleic acids Nucleotide sequence Packaging Protein engineering Ribonucleic acid RNA Science Sequence Homology, Amino Acid Spectrophotometry, Ultraviolet Vaccines Vaccines, Virus-Like Particle - immunology Virion - genetics Virion - immunology Virion - metabolism Virus Assembly - genetics Virus Assembly - immunology Virus-like particles Yeasts
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