Anticancer immunotherapy by CTLA-4 blockade： obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25

The cytotoxic T lymphocyte antigen-4 （CTLA-4）-blocking antibody ipilimumab induces immune-mediated longterm control of metastatic melanoma in a fraction of patients. Although ipilimumab undoubtedly exerts its therapeutic effects via immunostimulation, thus far clinically useful, immunologically rele...

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Veröffentlicht in:	Cell research 2015-02, Vol.25 (2), p.208-224
Hauptverfasser:	Hannani, Dalil, Vétizou, Marie, Enot, David, Rusakiewicz, Sylvie, Chaput, Nathalie, Klatzmann, David, Desbois, Melanie, Jacquelot, Nicolas, Vimond, Nadège, Chouaib, Salem, Mateus, Christine, Allison, James P, Ribas, Antoni, Wolchok, Jedd D, Yuan, Jianda, Wong, Philip, Postow, Michael, Mackiewicz, Andrzej, Mackiewicz, Jacek, Schadendorff, Dirk, Jaeger, Dirk, Korman, Alan J, Bahjat, Keith, Maio, Michele, Calabro, Luana, Teng, Michele WL, Smyth, Mark J, Eggermont, Alexander, Robert, Caroline, Kroemer, Guido, Zitvogel, Laurence
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/2325 692/698/1543/1565/1597/554/1834/1269 692/699/67/1813/1634 692/699/67/1857 Adolescent Adult Aged Aged, 80 and over Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Biomedical and Life Sciences CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Biology Cohort Studies CTLA-4 CTLA-4 Antigen - immunology CTLA-4 Antigen - metabolism Disease Models, Animal Female Humans IL-2 Immunology Immunotherapy Interleukin-2 Receptor alpha Subunit - blood Interleukin-2 Receptor alpha Subunit - immunology Ipilimumab Life Sciences Lymphocytes Male Melanoma Melanoma - mortality Melanoma - pathology Melanoma - therapy Mice Mice, Inbred C57BL Middle Aged Neutralization Original original-article Receptors, Interleukin-2 - genetics Receptors, Interleukin-2 - immunology Receptors, Interleukin-2 - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - pharmacology T-Lymphocytes, Regulatory - immunology Up-Regulation - drug effects Young Adult 免疫治疗受体可溶性抗癌作用生物标志物细胞毒性T淋巴细胞
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