Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway

Mutations in tuberous sclerosis ( TSC ) genes cause the genetic disorder TSC, as well as other neoplasms, including lymphangioleiomyomatosis (LAM) and angiomyolipomas (AMLs). AMLs are benign renal tumors occur both in sporadic LAM and in TSC. As they carry the same mutations, AML cell lines serve as...

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Veröffentlicht in:	Cell death & disease 2014-12, Vol.5 (12), p.e1557-e1557
Hauptverfasser:	Makovski, V, Jacob-Hirsch, J, Gefen-Dor, C, Shai, B, Ehrlich, M, Rechavi, G, Kloog, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 13/95 38/109 38/39 38/61 38/77 38/90 631/67/1059/602 631/67/1534 631/80/86 96/1 Angiomyolipoma - genetics Angiomyolipoma - metabolism Angiomyolipoma - pathology Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Proliferation - drug effects Farnesol - analogs & derivatives Farnesol - pharmacology Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Immunology Interferon Regulatory Factor-7 - antagonists & inhibitors Interferon Regulatory Factor-7 - genetics Interferon Regulatory Factor-7 - metabolism Kidney - metabolism Kidney - pathology Life Sciences Lymphangioleiomyomatosis - genetics Lymphangioleiomyomatosis - metabolism Lymphangioleiomyomatosis - pathology Microarray Analysis Monomeric GTP-Binding Proteins - antagonists & inhibitors Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Neuropeptides - antagonists & inhibitors Neuropeptides - genetics Neuropeptides - metabolism Original original-article Ras Homolog Enriched in Brain Protein RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Salicylates - pharmacology Signal Transduction Sirolimus - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Tumor Cells, Cultured Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - genetics
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