The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus

The central melanocortin system is essential for the regulation of long-term energy homeostasis in humans. Rodent experiments suggest that this system also affects glucose metabolism, in particular by modulating peripheral insulin sensitivity independently of its effect on adiposity. Rare patients w...

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Veröffentlicht in:	International Journal of Obesity 2014-01, Vol.38 (1), p.148-151
Hauptverfasser:	Aslan, I R, Ranadive, S A, Valle, I, Kollipara, S, Noble, J A, Vaisse, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/776/1178 692/420/2489/144 692/699/2743/137/1418 692/699/2743/393 Adrenal Insufficiency - complications Adrenal Insufficiency - genetics Biological and medical sciences Child Diabetes Diabetes Mellitus, Type 1 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Metabolism Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding Behavior Genes Genetic aspects Genotype Glucose Health Promotion and Disease Prevention Homeostasis Humans Hypothalamus Identification and classification Insulin resistance Insulin Resistance - genetics Internal Medicine Male Medical sciences Medicine Medicine & Public Health Melanocortins - genetics Melanocortins - metabolism Metabolic Diseases Mutation Neuropeptides Obesity Obesity - complications Obesity - genetics Patients Pediatric Obesity - etiology Pediatric Obesity - genetics Pro-Opiomelanocortin - deficiency Pro-Opiomelanocortin - genetics Protein synthesis Proteins Public Health Rodents Sequence Analysis, DNA short-communication Weight Gain - genetics
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