Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle

Aims/hypothesis Muscle may experience hypoglycaemia during ischaemia or insulin infusion. During severe hypoglycaemia energy production is blocked, and an increase of AMP:ATP activates the energy sensor and putative insulin-sensitiser AMP-activated protein kinase (AMPK). AMPK promotes energy conserv...

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Veröffentlicht in:Diabetologia 2012-03, Vol.55 (3), p.783-794
Hauptverfasser: Chopra, I., Li, H. F., Wang, H., Webster, K. A.
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Sprache:eng
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