An Autopsy Case of Rapidly Progressing Spindle Cell Carcinoma of the Lung Accompanied with Intratumor Hemorrhage

Spindle cell carcinoma (SPCC) of the lung is a subset of sarcomatoid carcinoma. Its clinical features are unclear because of its rarity. Here, we report an autopsy case of SPCC and review CT findings and chemotherapeutic regimens based on previous reports of this disease. To our knowledge, this is t...

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Veröffentlicht in:	The American journal of case reports 2015-11, Vol.16, p.805-810
Hauptverfasser:	Kida, Jun-ichiro, Kanaji, Nobuhiro, Kishi, Sosuke, Imaida, Katsumi, Bandoh, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Autopsy Carcinoma - blood supply Carcinoma - complications Carcinoma - diagnosis Fatal Outcome Hemorrhage - diagnosis Hemorrhage - etiology Humans Lung Neoplasms - blood supply Lung Neoplasms - complications Lung Neoplasms - diagnosis Male Neoplasm Staging Tomography, X-Ray Computed
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creator	Kida, Jun-ichiro Kanaji, Nobuhiro Kishi, Sosuke Imaida, Katsumi Bandoh, Shuji
description	Spindle cell carcinoma (SPCC) of the lung is a subset of sarcomatoid carcinoma. Its clinical features are unclear because of its rarity. Here, we report an autopsy case of SPCC and review CT findings and chemotherapeutic regimens based on previous reports of this disease. To our knowledge, this is the first reported case of pemetrexed used to treat SPCC. A 74-year-old Japanese male presented with dyspnea and contrast-enhanced computed tomography (CT) showed abundant left pleural effusion and a mass in lower lobe of the left lung. By the tumor biopsy, he was diagnosed for SPCC of the lung, cT3N0M1a, stage IV. The tumor was resistant to chemotherapy with carboplatin and pemetrexed, and rapidly progressed. Autopsy revealed abundant hemorrhage within the tumor, which apparently reflects a low-density area in CT. Present case and the accumulation of cases indicate that low-density areas in CT and rapid tumor progression may be common SPCC findings.
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subjects	Aged Autopsy Carcinoma - blood supply Carcinoma - complications Carcinoma - diagnosis Fatal Outcome Hemorrhage - diagnosis Hemorrhage - etiology Humans Lung Neoplasms - blood supply Lung Neoplasms - complications Lung Neoplasms - diagnosis Male Neoplasm Staging Tomography, X-Ray Computed
title	An Autopsy Case of Rapidly Progressing Spindle Cell Carcinoma of the Lung Accompanied with Intratumor Hemorrhage
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