A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence

Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such apparent functional redundancy exist in mammals. Here we charact...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes & development 2015-11, Vol.29 (21), p.2231-2243
Hauptverfasser:	Brien, Gerard L, Healy, Evan, Jerman, Emilia, Conway, Eric, Fadda, Elisa, O'Donovan, Darragh, Krivtsov, Andrei V, Rice, Alan M, Kearney, Conor J, Flaus, Andrew, McDade, Simon S, Martin, Seamus J, McLysaght, Aoife, O'Connell, David J, Armstrong, Scott A, Bracken, Adrian P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - genetics Cells, Cultured Chromatin - metabolism Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E2F Transcription Factors - metabolism Gene Expression Regulation, Neoplastic Humans Mice Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Protein Binding Protein Stability Protein Structure, Tertiary - genetics Research Paper Transcription Factors - metabolism Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!