Inhibition of HIV Expression and Integration in Macrophages by Methylglyoxal-Bis-Guanylhydrazone

Macrophages are a target for infection with HIV and represent one of the viral reservoirs that are relatively resistant to current antiretroviral drugs. Here we demonstrate that methylglyoxal-bis-guanylhydrazone (MGBG), a polyamine analog and potent S-adenosylmethionine decarboxylase inhibitor, decr...

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Veröffentlicht in:	Journal of virology 2015-11, Vol.89 (22), p.11176-11189
Hauptverfasser:	Jin, Xia, McGrath, Michael S, Xu, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Decarboxylase - antagonists & inhibitors Anti-Retroviral Agents - pharmacology Biological Transport, Active CD4 Antigens - biosynthesis Cells, Cultured Green Fluorescent Proteins - genetics HIV Core Protein p24 - biosynthesis HIV Infections - drug therapy HIV-1 - drug effects HIV-1 - genetics HIV-1 - growth & development Human immunodeficiency virus Human immunodeficiency virus 1 Humans Lentivirus Lipopolysaccharide Receptors - metabolism Macrophages - virology Mitoguazone - pharmacology Monocytes - virology Receptors, CCR5 - biosynthesis Retroviridae Vaccines and Antiviral Agents Virus Integration - drug effects Virus Replication - drug effects
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