Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria

Peroxidic antimalarial agents including the sequiterpene artemisinins and the synthetic 1,2,4-trioxolanes function via initial intraparasitic reduction of an endoperoxide bond. By chemically coupling this reduction to release of a tethered drug species it is possible to confer two distinct pharmacol...

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Veröffentlicht in:	ACS medicinal chemistry letters 2015-11, Vol.6 (11), p.1145-1149
Hauptverfasser:	Lauterwasser, Erica M. W, Fontaine, Shaun D, Li, Hao, Gut, Jiri, Katneni, Kasiram, Charman, Susan A, Rosenthal, Philip J, Bogyo, Matthew, Renslo, Adam R
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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