Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure

Therapeutic options for brain infections caused by pathogens with a reduced sensitivity to drugs are limited. Recent reports on the potential use of linezolid in treating brain infections prompted us to design novel compounds around this scaffold. Herein, we describe the design and synthesis of vari...

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Veröffentlicht in:ACS medicinal chemistry letters 2015-11, Vol.6 (11), p.1105-1110
Hauptverfasser: Seetharamsingh, B, Ramesh, Remya, Dange, Santoshkumar S, Khairnar, Pankaj V, Singhal, Smita, Upadhyay, Dilip, Veeraraghavan, Sridhar, Viswanadha, Srikant, Vakkalanka, Swaroop, Reddy, D. Srinivasa
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Sprache:eng
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