Prevalence and molecular characterizations of enterovirus D68 among children with acute respiratory infection in China between 2012 and 2014
EV-D68 is associated with respiratory tract infections (RTIs). Since its first isolation, EV-D68 has been detected sporadically. However, the US and Canada have experienced outbreaks of EV-D68 infections between August and December 2014. This study aimed to investigate the molecular epidemiology and...
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| Veröffentlicht in: | Scientific reports 2015-11, Vol.5 (1), p.16639-16639, Article 16639 |
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| description | EV-D68 is associated with respiratory tract infections (RTIs). Since its first isolation, EV-D68 has been detected sporadically. However, the US and Canada have experienced outbreaks of EV-D68 infections between August and December 2014. This study aimed to investigate the molecular epidemiology and clinical characteristics of EV-D68 in Chongqing, Southwestern China. From January 2012 to November 2014, 1876 nasopharyngeal aspirate specimens (NPAs) were collected from hospitalized children with RTIs. Among the 1876 NPAs, EV-D68 was detected in 19 samples (1.0%, 19/1876). Of these, 13 samples were detected in September and October 2014 (9.8%, 13/132). Phylogenetic analysis showed that all 13 strains detected in the 2014 Chongqing had high homology with the main strains of the 2014 US outbreak. Among the children with EV-D68 infection, 13 (68%) had a history of recurrent wheezing. A total of 13 children had a discharge diagnosis of asthma. Of these, 11 children were diagnosed with acute asthma exacerbation. EV-D68 was the predominant pathogen that evoked asthma exacerbation in September and October 2014. In conclusion, our results found that a history of recurrent wheezing may be a risk factor for the detection of EV-D68 and viral-induced asthma exacerbation may be a clinical feature of EV-D68 infection. |
| doi_str_mv | 10.1038/srep16639 |
| format | Article |
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Since its first isolation, EV-D68 has been detected sporadically. However, the US and Canada have experienced outbreaks of EV-D68 infections between August and December 2014. This study aimed to investigate the molecular epidemiology and clinical characteristics of EV-D68 in Chongqing, Southwestern China. From January 2012 to November 2014, 1876 nasopharyngeal aspirate specimens (NPAs) were collected from hospitalized children with RTIs. Among the 1876 NPAs, EV-D68 was detected in 19 samples (1.0%, 19/1876). Of these, 13 samples were detected in September and October 2014 (9.8%, 13/132). Phylogenetic analysis showed that all 13 strains detected in the 2014 Chongqing had high homology with the main strains of the 2014 US outbreak. Among the children with EV-D68 infection, 13 (68%) had a history of recurrent wheezing. A total of 13 children had a discharge diagnosis of asthma. Of these, 11 children were diagnosed with acute asthma exacerbation. EV-D68 was the predominant pathogen that evoked asthma exacerbation in September and October 2014. In conclusion, our results found that a history of recurrent wheezing may be a risk factor for the detection of EV-D68 and viral-induced asthma exacerbation may be a clinical feature of EV-D68 infection.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep16639</identifier><identifier>PMID: 26568267</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>5' Untranslated Regions ; 692/308/174 ; 692/699/255/2514 ; Acute Disease ; Asthma ; Asthma - diagnosis ; Base Sequence ; Child ; Child, Preschool ; Children ; China - epidemiology ; Disease Outbreaks ; Enterovirus D, Human - classification ; Enterovirus D, Human - genetics ; Enterovirus D, Human - isolation & purification ; Enterovirus Infections - epidemiology ; Enterovirus Infections - pathology ; Enterovirus Infections - virology ; Epidemiology ; Female ; Homology ; Humanities and Social Sciences ; Humans ; Infant ; Infections ; Male ; multidisciplinary ; Outbreaks ; Phylogeny ; Prevalence ; Recurrence ; Recurrent infection ; Respiratory Sounds - diagnosis ; Respiratory tract ; Respiratory tract diseases ; Respiratory tract infection ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - pathology ; Respiratory Tract Infections - virology ; Risk factors ; Science ; Sequence Analysis, RNA ; Viral Proteins - genetics ; Wheezing</subject><ispartof>Scientific reports, 2015-11, Vol.5 (1), p.16639-16639, Article 16639</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Nov 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-64d28b434b50cd98cb7e476d51c4b16686293fe9076343076b33517dbf6a3f6a3</citedby><cites>FETCH-LOGICAL-c438t-64d28b434b50cd98cb7e476d51c4b16686293fe9076343076b33517dbf6a3f6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644992/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644992/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26568267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Qiuyan</creatorcontrib><creatorcontrib>Ren, Luo</creatorcontrib><creatorcontrib>Zheng, Shouyan</creatorcontrib><creatorcontrib>Wang, Lili</creatorcontrib><creatorcontrib>Xie, Xiaohong</creatorcontrib><creatorcontrib>Deng, Yu</creatorcontrib><creatorcontrib>Zhao, Yao</creatorcontrib><creatorcontrib>Zhao, Xiaodong</creatorcontrib><creatorcontrib>Luo, Zhengxiu</creatorcontrib><creatorcontrib>Fu, Zhou</creatorcontrib><creatorcontrib>Huang, Ailong</creatorcontrib><creatorcontrib>Liu, Enmei</creatorcontrib><title>Prevalence and molecular characterizations of enterovirus D68 among children with acute respiratory infection in China between 2012 and 2014</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>EV-D68 is associated with respiratory tract infections (RTIs). Since its first isolation, EV-D68 has been detected sporadically. However, the US and Canada have experienced outbreaks of EV-D68 infections between August and December 2014. This study aimed to investigate the molecular epidemiology and clinical characteristics of EV-D68 in Chongqing, Southwestern China. From January 2012 to November 2014, 1876 nasopharyngeal aspirate specimens (NPAs) were collected from hospitalized children with RTIs. Among the 1876 NPAs, EV-D68 was detected in 19 samples (1.0%, 19/1876). Of these, 13 samples were detected in September and October 2014 (9.8%, 13/132). Phylogenetic analysis showed that all 13 strains detected in the 2014 Chongqing had high homology with the main strains of the 2014 US outbreak. Among the children with EV-D68 infection, 13 (68%) had a history of recurrent wheezing. A total of 13 children had a discharge diagnosis of asthma. Of these, 11 children were diagnosed with acute asthma exacerbation. EV-D68 was the predominant pathogen that evoked asthma exacerbation in September and October 2014. In conclusion, our results found that a history of recurrent wheezing may be a risk factor for the detection of EV-D68 and viral-induced asthma exacerbation may be a clinical feature of EV-D68 infection.</description><subject>5' Untranslated Regions</subject><subject>692/308/174</subject><subject>692/699/255/2514</subject><subject>Acute Disease</subject><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Base Sequence</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>China - epidemiology</subject><subject>Disease Outbreaks</subject><subject>Enterovirus D, Human - classification</subject><subject>Enterovirus D, Human - genetics</subject><subject>Enterovirus D, Human - isolation & purification</subject><subject>Enterovirus Infections - epidemiology</subject><subject>Enterovirus Infections - pathology</subject><subject>Enterovirus Infections - virology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Homology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infant</subject><subject>Infections</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Outbreaks</subject><subject>Phylogeny</subject><subject>Prevalence</subject><subject>Recurrence</subject><subject>Recurrent infection</subject><subject>Respiratory Sounds - diagnosis</subject><subject>Respiratory tract</subject><subject>Respiratory tract diseases</subject><subject>Respiratory tract infection</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - pathology</subject><subject>Respiratory Tract Infections - virology</subject><subject>Risk factors</subject><subject>Science</subject><subject>Sequence Analysis, RNA</subject><subject>Viral Proteins - genetics</subject><subject>Wheezing</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkVtrFDEUxwex2NL2wS8gAV9U2JrbZJIXQdZboaAP-hwymTO7KTPJmsxsqZ_BD-1Zty6rBpIccn75n1tVPWX0ilGhX5cMG6aUMI-qM05lveCC88dH9ml1WcotxVVzI5l5Up1yVSvNVXNW_fySYesGiB6Iix0Z0wB-Hlwmfu2y8xPk8MNNIcVCUk8g4kPahjwX8k5p4sYUV4iGocsQyV2Y1sT5eQKSoWxCdlPK9yTEHvxOAy2yXIfoSAvTHeAPThn_HRgNeVGd9G4ocPlwn1ffPrz_uvy0uPn88Xr59mbhpdDTQsmO61YK2dbUd0b7tgHZqK5mXrbYCq24ET0Y2ighBZ6tEDVrurZXTuz2efVmr7uZ2xE6j1VlN9hNDqPL9za5YP_2xLC2q7S1UklpDEeBFw8COX2foUx2DMXDMLgIaS6WNaLGmNhwRJ__g96mOUcszzJtjKaS0Rqpl3vK51Rwov0hGUbtbsz2MGZknx1nfyD_DBWBV3ugoCuuIB-F_E_tFyjcshM</recordid><startdate>20151116</startdate><enddate>20151116</enddate><creator>Xiao, Qiuyan</creator><creator>Ren, Luo</creator><creator>Zheng, Shouyan</creator><creator>Wang, Lili</creator><creator>Xie, Xiaohong</creator><creator>Deng, Yu</creator><creator>Zhao, Yao</creator><creator>Zhao, Xiaodong</creator><creator>Luo, Zhengxiu</creator><creator>Fu, Zhou</creator><creator>Huang, Ailong</creator><creator>Liu, Enmei</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151116</creationdate><title>Prevalence and molecular characterizations of enterovirus D68 among children with acute respiratory infection in China between 2012 and 2014</title><author>Xiao, Qiuyan ; Ren, Luo ; Zheng, Shouyan ; Wang, Lili ; Xie, Xiaohong ; Deng, Yu ; Zhao, Yao ; Zhao, Xiaodong ; Luo, Zhengxiu ; Fu, Zhou ; Huang, Ailong ; Liu, Enmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-64d28b434b50cd98cb7e476d51c4b16686293fe9076343076b33517dbf6a3f6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>5' Untranslated Regions</topic><topic>692/308/174</topic><topic>692/699/255/2514</topic><topic>Acute Disease</topic><topic>Asthma</topic><topic>Asthma - 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epidemiology</topic><topic>Respiratory Tract Infections - pathology</topic><topic>Respiratory Tract Infections - virology</topic><topic>Risk factors</topic><topic>Science</topic><topic>Sequence Analysis, RNA</topic><topic>Viral Proteins - genetics</topic><topic>Wheezing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Qiuyan</creatorcontrib><creatorcontrib>Ren, Luo</creatorcontrib><creatorcontrib>Zheng, Shouyan</creatorcontrib><creatorcontrib>Wang, Lili</creatorcontrib><creatorcontrib>Xie, Xiaohong</creatorcontrib><creatorcontrib>Deng, Yu</creatorcontrib><creatorcontrib>Zhao, Yao</creatorcontrib><creatorcontrib>Zhao, Xiaodong</creatorcontrib><creatorcontrib>Luo, Zhengxiu</creatorcontrib><creatorcontrib>Fu, Zhou</creatorcontrib><creatorcontrib>Huang, Ailong</creatorcontrib><creatorcontrib>Liu, Enmei</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Qiuyan</au><au>Ren, Luo</au><au>Zheng, Shouyan</au><au>Wang, Lili</au><au>Xie, Xiaohong</au><au>Deng, Yu</au><au>Zhao, Yao</au><au>Zhao, Xiaodong</au><au>Luo, Zhengxiu</au><au>Fu, Zhou</au><au>Huang, Ailong</au><au>Liu, Enmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and molecular characterizations of enterovirus D68 among children with acute respiratory infection in China between 2012 and 2014</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-11-16</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>16639</spage><epage>16639</epage><pages>16639-16639</pages><artnum>16639</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>EV-D68 is associated with respiratory tract infections (RTIs). Since its first isolation, EV-D68 has been detected sporadically. However, the US and Canada have experienced outbreaks of EV-D68 infections between August and December 2014. This study aimed to investigate the molecular epidemiology and clinical characteristics of EV-D68 in Chongqing, Southwestern China. From January 2012 to November 2014, 1876 nasopharyngeal aspirate specimens (NPAs) were collected from hospitalized children with RTIs. Among the 1876 NPAs, EV-D68 was detected in 19 samples (1.0%, 19/1876). Of these, 13 samples were detected in September and October 2014 (9.8%, 13/132). Phylogenetic analysis showed that all 13 strains detected in the 2014 Chongqing had high homology with the main strains of the 2014 US outbreak. Among the children with EV-D68 infection, 13 (68%) had a history of recurrent wheezing. A total of 13 children had a discharge diagnosis of asthma. Of these, 11 children were diagnosed with acute asthma exacerbation. EV-D68 was the predominant pathogen that evoked asthma exacerbation in September and October 2014. In conclusion, our results found that a history of recurrent wheezing may be a risk factor for the detection of EV-D68 and viral-induced asthma exacerbation may be a clinical feature of EV-D68 infection.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26568267</pmid><doi>10.1038/srep16639</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 5' Untranslated Regions 692/308/174 692/699/255/2514 Acute Disease Asthma Asthma - diagnosis Base Sequence Child Child, Preschool Children China - epidemiology Disease Outbreaks Enterovirus D, Human - classification Enterovirus D, Human - genetics Enterovirus D, Human - isolation & purification Enterovirus Infections - epidemiology Enterovirus Infections - pathology Enterovirus Infections - virology Epidemiology Female Homology Humanities and Social Sciences Humans Infant Infections Male multidisciplinary Outbreaks Phylogeny Prevalence Recurrence Recurrent infection Respiratory Sounds - diagnosis Respiratory tract Respiratory tract diseases Respiratory tract infection Respiratory Tract Infections - epidemiology Respiratory Tract Infections - pathology Respiratory Tract Infections - virology Risk factors Science Sequence Analysis, RNA Viral Proteins - genetics Wheezing |
| title | Prevalence and molecular characterizations of enterovirus D68 among children with acute respiratory infection in China between 2012 and 2014 |
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