Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in the United States. Risk prediction based on identifying germline mutations in ovarian cancer susceptibility genes could have a clinically significant impact on reducing disease mort...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2015-11, Vol.107 (11), p.1
Hauptverfasser:	Ramus, Susan J, Song, Honglin, Dicks, Ed, Tyrer, Jonathan P, Rosenthal, Adam N, Intermaggio, Maria P, Fraser, Lindsay, Gentry-Maharaj, Aleksandra, Hayward, Jane, Philpott, Susan, Anderson, Christopher, Edlund, Christopher K, Conti, David, Harrington, Patricia, Barrowdale, Daniel, Bowtell, David D, Alsop, Kathryn, Mitchell, Gillian, Cicek, Mine S, Cunningham, Julie M, Fridley, Brooke L, Alsop, Jennifer, Jimenez-Linan, Mercedes, Poblete, Samantha, Lele, Shashi, Sucheston-Campbell, Lara, Moysich, Kirsten B, Sieh, Weiva, McGuire, Valerie, Lester, Jenny, Bogdanova, Natalia, Dürst, Matthias, Hillemanns, Peter, Odunsi, Kunle, Whittemore, Alice S, Karlan, Beth Y, Dörk, Thilo, Goode, Ellen L, Menon, Usha, Jacobs, Ian J, Antoniou, Antonis C, Pharoah, Paul D P, Gayther, Simon A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Carcinoma, Ovarian Epithelial Cell Cycle Proteins - genetics Disease prevention DNA-Binding Proteins - genetics Epidemiology Fanconi Anemia Complementation Group N Protein Fanconi Anemia Complementation Group Proteins Female Genetic Predisposition to Disease Germ-Line Mutation High-Throughput Nucleotide Sequencing Humans Middle Aged Mutation Mutation, Missense Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - mortality Nuclear Proteins - genetics Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Predictive Value of Tests Risk Risk assessment RNA Helicases - genetics Tumor Suppressor Proteins - genetics Ubiquitin-Protein Ligases - genetics United States - epidemiology White People
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