Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice

Quantification of proteomes by mass spectrometry has proven to be useful to study human pathology recapitulated in cellular or animal models of disease. Enriching and quantifying newly synthesized proteins (NSPs) at set time points by mass spectrometry has the potential to identify important early r...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of proteome research 2015-11, Vol.14 (11), p.4815-4822
Hauptverfasser:	McClatchy, Daniel B, Ma, Yuanhui, Liu, Chao, Stein, Benjamin D, Martínez-Bartolomé, Salvador, Vasquez, Debbie, Hellberg, Kristina, Shaw, Reuben J, Yates, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - administration & dosage Alanine - analogs & derivatives Alanine - metabolism Alkynes - chemistry amino acids animal models Animals Azides - chemistry Biotin - chemistry Click Chemistry Food, Formulated Gene Expression Integrases - genetics Integrases - metabolism knockout mutants liver Liver - chemistry Liver - drug effects Liver - metabolism Male mass spectrometry Methionine - deficiency Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Annotation protein synthesis Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics proteome Proteome - genetics Proteome - isolation & purification Proteome - metabolism Proteomics - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!