Research progress and prospects of markers for liver cancer stem cells
Liver cancer is a common malignancy and surgery is the main treatment strategy. However, the prognosis is still poor because of high frequencies of postoperative recurrence and metastasis. In recent years, cancer stem cell(CSC) theory has evolved with the concept of stem cells, and has been applied...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2015-11, Vol.21 (42), p.12190-12196 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Zhu, Cheng-Pei Wang, An-Qiang Zhang, Hao-Hai Wan, Xue-Shuai Yang, Xiao-Bo Chen, Shu-Guang Zhao, Hai-Tao |
| description | Liver cancer is a common malignancy and surgery is the main treatment strategy. However, the prognosis is still poor because of high frequencies of postoperative recurrence and metastasis. In recent years, cancer stem cell(CSC) theory has evolved with the concept of stem cells, and has been applied to oncological research. According to cancer stem cell theory, liver cancer can be radically cured only by eradication of liver cancer stem cells(LCSCs). This notion has lead to the isolation and identification of LCSCs, which has become a highly researched area. Analysis of LCSC markers is considered to be the primary method for identification of LCSCs. Here, we provide an overview of the current research progress and prospects of surface markers for LCSCs. |
| doi_str_mv | 10.3748/wjg.v21.i42.12190 |
| format | Article |
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However, the prognosis is still poor because of high frequencies of postoperative recurrence and metastasis. In recent years, cancer stem cell(CSC) theory has evolved with the concept of stem cells, and has been applied to oncological research. According to cancer stem cell theory, liver cancer can be radically cured only by eradication of liver cancer stem cells(LCSCs). This notion has lead to the isolation and identification of LCSCs, which has become a highly researched area. Analysis of LCSC markers is considered to be the primary method for identification of LCSCs. 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However, the prognosis is still poor because of high frequencies of postoperative recurrence and metastasis. In recent years, cancer stem cell(CSC) theory has evolved with the concept of stem cells, and has been applied to oncological research. According to cancer stem cell theory, liver cancer can be radically cured only by eradication of liver cancer stem cells(LCSCs). This notion has lead to the isolation and identification of LCSCs, which has become a highly researched area. Analysis of LCSC markers is considered to be the primary method for identification of LCSCs. 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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biomarkers, Tumor - metabolism cancer carcinoma Liver cells S Hepatocellular Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Minireviews Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Phenotype Predictive Value of Tests Prognosis Side-Population Cells - metabolism Side-Population Cells - pathology stem |
| title | Research progress and prospects of markers for liver cancer stem cells |
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