Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

Over the past 4 years, nearly 100 exome sequencing studies have revealed the high frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin remodelers in human cancer. Most of these mutations are within the genes encoding subunits of the BAF (Brg/Brahma-associated factors)...

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Veröffentlicht in:	Science advances 2015-06, Vol.1 (5), p.e1500447-e1500447
Hauptverfasser:	Kadoch, Cigall, Crabtree, Gerald R
Format:	Artikel
Sprache:	eng
Schlagworte:	Human Cancer Review Reviews SciAdv reviews
Online-Zugang:	Volltext
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