Beta1-Adrenergic Receptor-Mediated Dilation of Rat Cerebral Artery Requires Shaker-Type KV1 Channels on PSD95 Scaffold

Postsynaptic density-95 (PSD95) is a scaffolding protein in cerebral vascular smooth muscle cells (cVSMCs), which binds to Shaker-type K+ (KV1) channels and facilitates channel opening through phosphorylation by protein kinase A. β1-Adrenergic receptors (β1ARs) also have a binding motif for PSD95. F...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2015-09, Vol.35 (9), p.1537-1546
Hauptverfasser:	Moore, Christopher L, McClenahan, Samantha J, Hanvey, Hillary M, Jang, Dae-Song, Nelson, Piper L, Joseph, Biny K, Rhee, Sung W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Cerebral Arteries - physiology Disks Large Homolog 4 Protein Imidazoles - pharmacology Intracellular Signaling Peptides and Proteins - metabolism Isoproterenol - pharmacology Male Membrane Proteins - metabolism Norepinephrine - pharmacology Original Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta-1 - metabolism Shaker Superfamily of Potassium Channels - metabolism Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilation - physiology
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