Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia
Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity (‘functional hyperemia’). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ische...
Gespeichert in:
| Veröffentlicht in: | Journal of Cerebral Blood Flow & Metabolism 2015-06, Vol.35 (6), p.883-887 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 887 |
|---|---|
| container_issue | 6 |
| container_start_page | 883 |
| container_title | Journal of Cerebral Blood Flow & Metabolism |
| container_volume | 35 |
| creator | Fernandez-Klett, Francisco Priller, Josef |
| description | Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity (‘functional hyperemia’). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ischemia is associated with constrictions and death of capillary pericytes, followed by fibrotic reorganization of the ischemic tissue. The data suggest that precapillary arterioles and capillaries are major sites of hemodynamic regulation in the brain. |
| doi_str_mv | 10.1038/jcbfm.2015.60 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4640260</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1038_jcbfm.2015.60</sage_id><sourcerecordid>1684438410</sourcerecordid><originalsourceid>FETCH-LOGICAL-c619t-4c65a825a75969cc12f38cca3785deb1b951707596a01dd8a2f0c7dbba41513b3</originalsourceid><addsrcrecordid>eNqFkUFr3DAQRkVJabbbHnMtgl5KwBuNZcnypdBuus1CQktpoTchy-ONFttKJDsl_752NlmSUshJh3m8-TQfIUfAFsC4Otnasm4XKQOxkOwFmYEQRZIzkAdkxtIcEpmr34fkdYxbxpjiQrwih6lQghfAZuTi1N1giEhXQ2d757tIfU2_Y3D2tsdIXUeXGLAMpqGfG-8rumr8H_oDN0NjJp6arqLraC-xdeYNeVmbJuLb-3dOfq2-_FyeJeffvq6Xn84TK6Hok8xKYVQqTC4KWVgLac2VtYbnSlRYQlkIyNk0NAyqSpm0ZjavytJkIICXfE4-7rxXQ9liZbHrx4D6KrjWhFvtjdNPJ5271Bt_ozOZsVSyUfDhXhD89YCx162LFpvGdOiHqMf1kKmCg3welSrLuMpgsr7_B936IXTjJSaK5wLUePc5SXaUDT7GgPU-NzA9darvOtVTp_ou67vHn93TDyWOwPEOiGaDj1b-1_YXas6qtg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1683751885</pqid></control><display><type>article</type><title>Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SAGE Complete</source><source>PubMed Central</source><creator>Fernandez-Klett, Francisco ; Priller, Josef</creator><creatorcontrib>Fernandez-Klett, Francisco ; Priller, Josef</creatorcontrib><description>Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity (‘functional hyperemia’). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ischemia is associated with constrictions and death of capillary pericytes, followed by fibrotic reorganization of the ischemic tissue. The data suggest that precapillary arterioles and capillaries are major sites of hemodynamic regulation in the brain.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1038/jcbfm.2015.60</identifier><identifier>PMID: 25853910</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Brain - blood supply ; Brain - pathology ; Brain - physiopathology ; Brain Ischemia - pathology ; Brain Ischemia - physiopathology ; Cerebrovascular Circulation ; Humans ; Mini Review ; Pericytes - cytology ; Pericytes - pathology</subject><ispartof>Journal of Cerebral Blood Flow & Metabolism, 2015-06, Vol.35 (6), p.883-887</ispartof><rights>2015 ISCBFM</rights><rights>Copyright Nature Publishing Group Jun 2015</rights><rights>Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc. 2015 International Society for Cerebral Blood Flow & Metabolism, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c619t-4c65a825a75969cc12f38cca3785deb1b951707596a01dd8a2f0c7dbba41513b3</citedby><cites>FETCH-LOGICAL-c619t-4c65a825a75969cc12f38cca3785deb1b951707596a01dd8a2f0c7dbba41513b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640260/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640260/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,723,776,780,788,881,21798,27899,27901,27902,43597,43598,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25853910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernandez-Klett, Francisco</creatorcontrib><creatorcontrib>Priller, Josef</creatorcontrib><title>Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia</title><title>Journal of Cerebral Blood Flow & Metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity (‘functional hyperemia’). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ischemia is associated with constrictions and death of capillary pericytes, followed by fibrotic reorganization of the ischemic tissue. The data suggest that precapillary arterioles and capillaries are major sites of hemodynamic regulation in the brain.</description><subject>Animals</subject><subject>Brain - blood supply</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Cerebrovascular Circulation</subject><subject>Humans</subject><subject>Mini Review</subject><subject>Pericytes - cytology</subject><subject>Pericytes - pathology</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUFr3DAQRkVJabbbHnMtgl5KwBuNZcnypdBuus1CQktpoTchy-ONFttKJDsl_752NlmSUshJh3m8-TQfIUfAFsC4Otnasm4XKQOxkOwFmYEQRZIzkAdkxtIcEpmr34fkdYxbxpjiQrwih6lQghfAZuTi1N1giEhXQ2d757tIfU2_Y3D2tsdIXUeXGLAMpqGfG-8rumr8H_oDN0NjJp6arqLraC-xdeYNeVmbJuLb-3dOfq2-_FyeJeffvq6Xn84TK6Hok8xKYVQqTC4KWVgLac2VtYbnSlRYQlkIyNk0NAyqSpm0ZjavytJkIICXfE4-7rxXQ9liZbHrx4D6KrjWhFvtjdNPJ5271Bt_ozOZsVSyUfDhXhD89YCx162LFpvGdOiHqMf1kKmCg3welSrLuMpgsr7_B936IXTjJSaK5wLUePc5SXaUDT7GgPU-NzA9darvOtVTp_ou67vHn93TDyWOwPEOiGaDj1b-1_YXas6qtg</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Fernandez-Klett, Francisco</creator><creator>Priller, Josef</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia</title><author>Fernandez-Klett, Francisco ; Priller, Josef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c619t-4c65a825a75969cc12f38cca3785deb1b951707596a01dd8a2f0c7dbba41513b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Brain - blood supply</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - physiopathology</topic><topic>Cerebrovascular Circulation</topic><topic>Humans</topic><topic>Mini Review</topic><topic>Pericytes - cytology</topic><topic>Pericytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandez-Klett, Francisco</creatorcontrib><creatorcontrib>Priller, Josef</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Cerebral Blood Flow & Metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandez-Klett, Francisco</au><au>Priller, Josef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia</atitle><jtitle>Journal of Cerebral Blood Flow & Metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>35</volume><issue>6</issue><spage>883</spage><epage>887</epage><pages>883-887</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><abstract>Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity (‘functional hyperemia’). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ischemia is associated with constrictions and death of capillary pericytes, followed by fibrotic reorganization of the ischemic tissue. The data suggest that precapillary arterioles and capillaries are major sites of hemodynamic regulation in the brain.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>25853910</pmid><doi>10.1038/jcbfm.2015.60</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-678X |
| ispartof | Journal of Cerebral Blood Flow & Metabolism, 2015-06, Vol.35 (6), p.883-887 |
| issn | 0271-678X 1559-7016 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4640260 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SAGE Complete; PubMed Central |
| subjects | Animals Brain - blood supply Brain - pathology Brain - physiopathology Brain Ischemia - pathology Brain Ischemia - physiopathology Cerebrovascular Circulation Humans Mini Review Pericytes - cytology Pericytes - pathology |
| title | Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T17%3A20%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diverse%20Functions%20of%20Pericytes%20in%20Cerebral%20Blood%20Flow%20Regulation%20and%20Ischemia&rft.jtitle=Journal%20of%20Cerebral%20Blood%20Flow%20&%20Metabolism&rft.au=Fernandez-Klett,%20Francisco&rft.date=2015-06-01&rft.volume=35&rft.issue=6&rft.spage=883&rft.epage=887&rft.pages=883-887&rft.issn=0271-678X&rft.eissn=1559-7016&rft_id=info:doi/10.1038/jcbfm.2015.60&rft_dat=%3Cproquest_pubme%3E1684438410%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1683751885&rft_id=info:pmid/25853910&rft_sage_id=10.1038_jcbfm.2015.60&rfr_iscdi=true |