HSPB1 as a novel regulator of ferroptotic cancer cell death

Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 (HSPB1) is a negative regulator of ferroptotic cancer cell death. Erastin, a specific ferroptosis-inducing compound, stimulates...

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Veröffentlicht in:	Oncogene 2015-11, Vol.34 (45), p.5617-5625
Hauptverfasser:	Sun, X, Ou, Z, Xie, M, Kang, R, Fan, Y, Niu, X, Wang, H, Cao, L, Tang, D
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 631/67/1059/2326 96/109 96/2 Analysis Animal models Animals Antitumor activity Apoptosis Biochemistry Cancer Care and treatment Cell Biology Cell Death Complications and side effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Ferroptosis Heat shock factors Heat shock proteins Heat Shock Transcription Factors Heat-Shock Response - drug effects Heat-Shock Response - genetics HeLa Cells HSF1 protein HSP27 Heat-Shock Proteins - genetics HSP27 Heat-Shock Proteins - metabolism Human Genetics Humans Influence Internal Medicine Iron Iron - metabolism Kinases Medicine Medicine & Public Health Mice Mice, Inbred NOD Mice, SCID Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms, Experimental - drug therapy Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Oncology original-article Phosphorylation Phosphorylation - drug effects Phosphorylation - genetics Piperazines - pharmacology Protein kinase C Reactive oxygen species Reactive Oxygen Species - metabolism Transcription Factors - genetics Transcription Factors - metabolism Xenograft Model Antitumor Assays Xenografts
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