Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

Monocytes promote the early host response to infection releasing key pro-inflammatory cytokines, such as IL-1β. The biologically inactive IL-1β precursor is processed to active form by inflammasomes, multi-protein complexes activating caspase-1. Human monocytes exhibit an unconventional one-step pat...

Ausführliche Beschreibung