Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction

BACKGROUND—Heart failure with preserved ejection fraction (HFpEF) is associated with significant morbidity and mortality but is currently refractory to therapy. Despite limited evidence, heart rate reduction has been advocated, on the basis of physiological considerations, as a therapeutic strategy...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2015-11, Vol.132 (18), p.1719-1725
Hauptverfasser:	Pal, Nikhil, Sivaswamy, Nadiya, Mahmod, Masliza, Yavari, Arash, Rudd, Amelia, Singh, Satnam, Dawson, Dana K, Francis, Jane M, Dwight, Jeremy S, Watkins, Hugh, Neubauer, Stefan, Frenneaux, Michael, Ashrafian, Houman
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Asymptomatic Diseases Benzazepines - therapeutic use Biomarkers Cross-Over Studies Cyclic Nucleotide-Gated Cation Channels - antagonists & inhibitors Double-Blind Method Endpoint Determination Exercise Test Exercise Tolerance Female Heart Failure - blood Heart Failure - drug therapy Heart Failure - physiopathology Heart Rate - drug effects Humans Hypertension - blood Hypertension - drug therapy Hypertension - physiopathology Ivabradine Male Middle Aged Natriuretic Peptide, Brain - blood Original Oxygen Consumption - drug effects Sinoatrial Node - drug effects Sinoatrial Node - physiopathology Stroke Volume Treatment Failure
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