Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3

Mutations in the motor protein Myosin Vb (Myo5B) or the soluble NSF attachment protein receptor Syntaxin 3 (Stx3) disturb epithelial polarity and cause microvillus inclusion disease (MVID), a lethal hereditary enteropathy affecting neonates. To understand the molecular mechanism of Myo5B and Stx3 in...

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Veröffentlicht in:	The Journal of cell biology 2015-11, Vol.211 (3), p.587-604
Hauptverfasser:	Vogel, Georg F, Klee, Katharina M C, Janecke, Andreas R, Müller, Thomas, Hess, Michael W, Huber, Lukas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Cells Cell Line Cell Line, Tumor Cell Membrane - metabolism Cell Polarity - physiology Cellular biology Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Epithelial Cells - metabolism Epithelial Cells - physiology Exocytosis - physiology Genomes Glucose Transporter Type 5 - metabolism HEK293 Cells Humans Malabsorption Syndromes - metabolism Microvilli - metabolism Microvilli - pathology Mucolipidoses - metabolism Munc18 Proteins - metabolism Mutation Mutation - physiology Myosin Heavy Chains - metabolism Myosin Type V - metabolism Newborn babies Qa-SNARE Proteins - metabolism R-SNARE Proteins - metabolism rab GTP-Binding Proteins - metabolism Signal Transduction - physiology Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - metabolism Vesicular Transport Proteins - metabolism
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