Mice lacking the PSD-95–interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation and impaired contextual fear conditioning

Protein ubiquitination has a significant influence on diverse aspects of neuronal development and function. Dorfin, also known as Rnf19a, is a RING finger E3 ubiquitin ligase implicated in amyotrophic lateral sclerosis and Parkinson’s disease, but its in vivo functions have not been explored. We rep...

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Veröffentlicht in:	Scientific reports 2015-11, Vol.5 (1), p.16410-16410, Article 16410
Hauptverfasser:	Park, Hanwool, Yang, Jinhee, Kim, Ryunhee, Li, Yan, Lee, Yeunkum, Lee, Chungwoo, Park, Jongil, Lee, Dongmin, Kim, Hyun, Kim, Eunjoon
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 13/1 13/109 13/51 14/19 38/111 631/378/1595/2636 631/378/2591/2592 631/378/340 64/60 9/30 9/74 Amyotrophic lateral sclerosis Animals Conditioning, Classical Dentate gyrus Disks Large Homolog 4 Protein Excitatory Postsynaptic Potentials - genetics Fear Fear conditioning Gene Knockout Techniques Guanylate Kinases - metabolism Hippocampus Hippocampus - metabolism Homozygote Humanities and Social Sciences Learning Long-term potentiation Long-Term Potentiation - genetics Membrane Proteins - metabolism Memory Mice Mice, Knockout Movement disorders multidisciplinary Neurodegenerative diseases Neurogenesis Neurogenesis - genetics Parkinson's disease Pattern recognition Postsynaptic density proteins Protein Binding Protein Interaction Mapping Proteome Proteomics - methods Psychomotor Agitation - genetics Rodents Science Short term memory Spatial discrimination learning Spatial memory Synaptic plasticity Two-Hybrid System Techniques Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Ubiquitination
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