Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

Human African trypanosomiasis (HAT), Chagas disease and leishmaniasis, which are caused by the trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and Leishmania species, are among the most deadly neglected tropical diseases. The development of drugs that are active against several trypanosomatids...

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Veröffentlicht in:	European journal of medicinal chemistry 2015-11, Vol.105, p.120-137
Hauptverfasser:	Di Pietro, Ornella, Vicente-García, Esther, Taylor, Martin C., Berenguer, Diana, Viayna, Elisabet, Lanzoni, Anna, Sola, Irene, Sayago, Helena, Riera, Cristina, Fisa, Roser, Clos, M. Victòria, Pérez, Belén, Kelly, John M., Lavilla, Rodolfo, Muñoz-Torrero, Diego
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Animals Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Benzo[h][1,6]naphthyridines Brain permeability Cell Line Cell Survival - drug effects Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Dose-Response Relationship, Drug Electrophorus Leishmania infantum - drug effects Leishmanicidal agents Molecular Structure Parasitic Sensitivity Tests Povarov reaction Pyrano[3,2-c]quinolines Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Rats Research Paper Structure-Activity Relationship Trypanocidal agents Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - enzymology Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology
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