Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules

Summary Background Megakaryocytes express and store platelet factor 4 (PF4) in alpha granules. In vivo, PF4 is a clinically relevant, negative regulator of megakaryopoiesis and hematopoietic stem cell replication. These findings would suggest a regulated source of free intramedullary PF4. Objectives...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2015-10, Vol.13 (10), p.1888-1899
Hauptverfasser:	Lambert, M. P., Meng, R., Xiao, L., Harper, D. C., Marks, M. S., Kowalska, M. A., Poncz, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Bone marrow Cells, Cultured Cholesterol Cytoplasmic Granules - metabolism Cytoplasmic Granules - radiation effects diphtheria toxin Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Humans Immunohistochemistry Low Density Lipoprotein Receptor-Related Protein-1 megakaryocytes Megakaryocytes - metabolism Megakaryocytes - radiation effects Mice, Knockout Microscopy Microscopy, Confocal platelet factor 4 Platelet Factor 4 - deficiency Platelet Factor 4 - genetics Platelet Factor 4 - metabolism Proteins radiation injury Receptors, LDL - genetics Receptors, LDL - metabolism RNA Interference Stem cells thrombocytopenia Thrombocytopenia - blood Thrombocytopenia - genetics Thrombocytopenia - metabolism Thrombopoiesis Time Factors Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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