Comparing the effect of intravenous dexamethasone, intravenous ondansetron, and their combination on nausea and vomiting in cesarean section with spinal anesthesia
Nausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of postdelivery intra- and post-...
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| Veröffentlicht in: | Advanced biomedical research 2015, Vol.4 (1), p.230-230 |
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| creator | Sane, Shahryar Hasanlui, Mohammadamin Valizadeh Abbasivash, Rahman Mahoori, Alireza Hashemi, Seyed Taghi Rafiei, Fahime |
| description | Nausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of postdelivery intra- and post-operative nausea and vomiting during CS under spinal anesthesia.
A randomized, prospective, double-blind study was performed on 90 patients undergoing planned CS under spinal anesthesia. The patients received 4 mg ondansetron in Group O, 8 mg dexamethasone in Group D, and 4 mg ondansetron +8 mg dexamethasone in Group OD intravenously within 1-2 min after the umbilical cord was clamped. Frequency of postdelivery intra- and post-operative nausea and vomiting episodes was recorded.
A total of 90 eligible patients were included in the study. There were 30 patients in Group O, 30 patients in Group D, and 30 patients in Group OD. Intraoperative nausea in Group D was more than the other two groups. Postoperative nausea in group OD was lesser than the other two groups. Intraoperative vomiting in Group OD was lesser than the other two groups. There was no statistically significant difference among the groups in postoperative vomiting (P > 0.05).
Combined use of dexamethasone and ondansetron for the same indication seems to increase the antiemetic efficacy. |
| doi_str_mv | 10.4103/2277-9175.167030 |
| format | Article |
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A randomized, prospective, double-blind study was performed on 90 patients undergoing planned CS under spinal anesthesia. The patients received 4 mg ondansetron in Group O, 8 mg dexamethasone in Group D, and 4 mg ondansetron +8 mg dexamethasone in Group OD intravenously within 1-2 min after the umbilical cord was clamped. Frequency of postdelivery intra- and post-operative nausea and vomiting episodes was recorded.
A total of 90 eligible patients were included in the study. There were 30 patients in Group O, 30 patients in Group D, and 30 patients in Group OD. Intraoperative nausea in Group D was more than the other two groups. Postoperative nausea in group OD was lesser than the other two groups. Intraoperative vomiting in Group OD was lesser than the other two groups. There was no statistically significant difference among the groups in postoperative vomiting (P > 0.05).
Combined use of dexamethasone and ondansetron for the same indication seems to increase the antiemetic efficacy.</description><identifier>ISSN: 2277-9175</identifier><identifier>EISSN: 2277-9175</identifier><identifier>DOI: 10.4103/2277-9175.167030</identifier><identifier>PMID: 26623405</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Anesthesia ; Dexamethasone ; Medical research ; Nausea ; Original ; Steroids (Organic compounds)</subject><ispartof>Advanced biomedical research, 2015, Vol.4 (1), p.230-230</ispartof><rights>COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright: © 2015 Advanced Biomedical Research 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3420-c40859daabbd197aa8099aebaf5426ad3c2a5ffce9e1892c5398524c9b24e7ae3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638052/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638052/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,4010,27902,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26623405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sane, Shahryar</creatorcontrib><creatorcontrib>Hasanlui, Mohammadamin Valizadeh</creatorcontrib><creatorcontrib>Abbasivash, Rahman</creatorcontrib><creatorcontrib>Mahoori, Alireza</creatorcontrib><creatorcontrib>Hashemi, Seyed Taghi</creatorcontrib><creatorcontrib>Rafiei, Fahime</creatorcontrib><title>Comparing the effect of intravenous dexamethasone, intravenous ondansetron, and their combination on nausea and vomiting in cesarean section with spinal anesthesia</title><title>Advanced biomedical research</title><addtitle>Adv Biomed Res</addtitle><description>Nausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of postdelivery intra- and post-operative nausea and vomiting during CS under spinal anesthesia.
A randomized, prospective, double-blind study was performed on 90 patients undergoing planned CS under spinal anesthesia. The patients received 4 mg ondansetron in Group O, 8 mg dexamethasone in Group D, and 4 mg ondansetron +8 mg dexamethasone in Group OD intravenously within 1-2 min after the umbilical cord was clamped. Frequency of postdelivery intra- and post-operative nausea and vomiting episodes was recorded.
A total of 90 eligible patients were included in the study. There were 30 patients in Group O, 30 patients in Group D, and 30 patients in Group OD. Intraoperative nausea in Group D was more than the other two groups. Postoperative nausea in group OD was lesser than the other two groups. Intraoperative vomiting in Group OD was lesser than the other two groups. There was no statistically significant difference among the groups in postoperative vomiting (P > 0.05).
Combined use of dexamethasone and ondansetron for the same indication seems to increase the antiemetic efficacy.</description><subject>Anesthesia</subject><subject>Dexamethasone</subject><subject>Medical research</subject><subject>Nausea</subject><subject>Original</subject><subject>Steroids (Organic compounds)</subject><issn>2277-9175</issn><issn>2277-9175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNptkl2L1DAUhoso7rLuvVcS8EZhZ0yTtGluhGXwY2FB8OM6nKYnM5E2GZPMuP4e_6ipsw47YHPRkvO8b3pO3qp6XtOlqCl_w5iUC1XLZlm3knL6qDo_bj1-8H1WXab0nZan7UTbqKfVGWtbxgVtzqvfqzBtITq_JnmDBK1Fk0mwxPkcYY8-7BIZ8A4mzBtIwePVSSn4AXzCHIO_IuCH2cVFYsLUOw_ZBV8Q4mGXEP7W92FyeT7OeWIwQUTwJJVDZ_SnyxuStkU5FhhTMUsOnlVPLIwJL-_fF9W39---rj4ubj99uFld3y4MF4wujKBdowaAvh9qJQE6qhRgD7YRrIWBGwaNtQYV1p1ipuGqa5gwqmcCJSC_qN4efLe7fsLB4NznqLfRTRB_6QBOn1a82-h12GvR8o42rBi8ujeI4ceu_L6eXDI4jqWXMixdS6FaWkulCvrygK5hRO28DcXRzLi-FpKXRiSThVr-hyprwMmZchnWlf0TwesTQWEy3uV1mX_SN18-n7L0wJoYUopoj53WVM8J03OE9BwhfUhYkbx4OKGj4F-e-B8kYM87</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Sane, Shahryar</creator><creator>Hasanlui, Mohammadamin Valizadeh</creator><creator>Abbasivash, Rahman</creator><creator>Mahoori, Alireza</creator><creator>Hashemi, Seyed Taghi</creator><creator>Rafiei, Fahime</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2015</creationdate><title>Comparing the effect of intravenous dexamethasone, intravenous ondansetron, and their combination on nausea and vomiting in cesarean section with spinal anesthesia</title><author>Sane, Shahryar ; Hasanlui, Mohammadamin Valizadeh ; Abbasivash, Rahman ; Mahoori, Alireza ; Hashemi, Seyed Taghi ; Rafiei, Fahime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3420-c40859daabbd197aa8099aebaf5426ad3c2a5ffce9e1892c5398524c9b24e7ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anesthesia</topic><topic>Dexamethasone</topic><topic>Medical research</topic><topic>Nausea</topic><topic>Original</topic><topic>Steroids (Organic compounds)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sane, Shahryar</creatorcontrib><creatorcontrib>Hasanlui, Mohammadamin Valizadeh</creatorcontrib><creatorcontrib>Abbasivash, Rahman</creatorcontrib><creatorcontrib>Mahoori, Alireza</creatorcontrib><creatorcontrib>Hashemi, Seyed Taghi</creatorcontrib><creatorcontrib>Rafiei, Fahime</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced biomedical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sane, Shahryar</au><au>Hasanlui, Mohammadamin Valizadeh</au><au>Abbasivash, Rahman</au><au>Mahoori, Alireza</au><au>Hashemi, Seyed Taghi</au><au>Rafiei, Fahime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparing the effect of intravenous dexamethasone, intravenous ondansetron, and their combination on nausea and vomiting in cesarean section with spinal anesthesia</atitle><jtitle>Advanced biomedical research</jtitle><addtitle>Adv Biomed Res</addtitle><date>2015</date><risdate>2015</risdate><volume>4</volume><issue>1</issue><spage>230</spage><epage>230</epage><pages>230-230</pages><issn>2277-9175</issn><eissn>2277-9175</eissn><abstract>Nausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of postdelivery intra- and post-operative nausea and vomiting during CS under spinal anesthesia.
A randomized, prospective, double-blind study was performed on 90 patients undergoing planned CS under spinal anesthesia. The patients received 4 mg ondansetron in Group O, 8 mg dexamethasone in Group D, and 4 mg ondansetron +8 mg dexamethasone in Group OD intravenously within 1-2 min after the umbilical cord was clamped. Frequency of postdelivery intra- and post-operative nausea and vomiting episodes was recorded.
A total of 90 eligible patients were included in the study. There were 30 patients in Group O, 30 patients in Group D, and 30 patients in Group OD. Intraoperative nausea in Group D was more than the other two groups. Postoperative nausea in group OD was lesser than the other two groups. Intraoperative vomiting in Group OD was lesser than the other two groups. There was no statistically significant difference among the groups in postoperative vomiting (P > 0.05).
Combined use of dexamethasone and ondansetron for the same indication seems to increase the antiemetic efficacy.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>26623405</pmid><doi>10.4103/2277-9175.167030</doi><oa>free_for_read</oa></addata></record> |
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| source | Medknow Open Access Medical Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Anesthesia Dexamethasone Medical research Nausea Original Steroids (Organic compounds) |
| title | Comparing the effect of intravenous dexamethasone, intravenous ondansetron, and their combination on nausea and vomiting in cesarean section with spinal anesthesia |
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