Phosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance in Breast Cancer

Tamoxifen, an estrogen receptor-α (ER) antagonist, is an important agent for the treatment of breast cancer. However, this therapy is complicated by the fact that a substantial number of patients exhibit either de novo or acquired resistance. To characterize the signaling mechanisms underlying this...

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Veröffentlicht in:	Molecular & cellular proteomics 2015-11, Vol.14 (11), p.2887-2900
Hauptverfasser:	Wu, Xinyan, Zahari, Muhammad Saddiq, Renuse, Santosh, Nirujogi, Raja Sekhar, Kim, Min-Sik, Manda, Srikanth S., Stearns, Vered, Gabrielson, Edward, Sukumar, Saraswati, Pandey, Akhilesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - therapy Animals Antineoplastic Agents, Hormonal - pharmacology Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Cell Proliferation Drug Resistance, Neoplasm - genetics Female Focal Adhesion Kinase 2 - antagonists & inhibitors Focal Adhesion Kinase 2 - genetics Focal Adhesion Kinase 2 - metabolism Gene Expression Regulation, Neoplastic Humans Isotope Labeling MCF-7 Cells Mice Mice, Nude Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Proteome - genetics Proteome - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction Survival Analysis Tamoxifen - pharmacology Transcriptional Activation Tumor Burden Xenograft Model Antitumor Assays
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