Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway

Magnolol, the major active compound found in Magnolia officinalis has a wide range of clinical applications due to its anti‐inflammation and anti‐oxidation effects. This study investigated the effects of magnolol on the growth of human gallbladder carcinoma (GBC) cell lines. The results indicated th...

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Veröffentlicht in:	Cancer science 2015-10, Vol.106 (10), p.1341-1350
Hauptverfasser:	Li, Maolan, Zhang, Fei, Wang, Xu'an, Wu, Xiangsong, Zhang, Bingtai, Zhang, Ning, Wu, Wenguang, Wang, Zheng, Weng, Hao, Liu, Shibo, Gao, Guofeng, Mu, Jiasheng, Shu, Yijun, Bao, Runfa, Cao, Yang, Lu, Jianhua, Gu, Jun, Zhu, Jian, Liu, Yingbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biphenyl Compounds - pharmacology Cancer cdc25 Phosphatases - biosynthesis Cell culture Cell cycle cell cycle arrest Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cyclin D1 Cyclin D1 - biosynthesis Cyclin-dependent kinase 2 Cyclin-Dependent Kinase 2 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - metabolism Deoxyribonucleic acid DNA DNA damage G1 phase G1 Phase Cell Cycle Checkpoints - drug effects Gallbladder Gallbladder cancer gallbladder carcinoma Gallbladder Neoplasms - drug therapy Gallbladder Neoplasms - pathology GTP-binding protein Human Umbilical Vein Endothelial Cells Humans Kinases Lignans - pharmacology Magnolia magnolol Medical prognosis Medicine, Chinese Traditional Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred BALB C Mice, Nude Mitochondria Nitric Oxide Synthase - antagonists & inhibitors Original Oxidation p53 pathways p53 Protein Patients R&D Research & development Therapeutic applications Tumor cell lines Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays
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