The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in Man
The redeployment of NK-cells in response to an acute bout of exercise is thought to be an integral component of the “fight-or-flight” response, preparing the body for potential injury or infection. We showed previously that CMV seropositivity impairs the redeployment of NK-cells with exercise in the...
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| creator | Simpson, Richard J. Agha, Nadia Spielmann, Guillaume Bigley, Austin B. |
| description | The redeployment of NK-cells in response to an acute bout of exercise is thought to be an integral component of the “fight-or-flight” response, preparing the body for potential injury or infection. We showed previously that CMV seropositivity impairs the redeployment of NK-cells with exercise in the young. In the current study, we examined the effect of aging on the redeployment of NK-cells with exercise in the context of CMV. We show here that CMV blunts the exercise-induced redeployment of NK-cells in both younger (23–39 yrs) and older (50–64 yrs) subjects with older CMVneg subjects showing the largest postexercise mobilization and 1 h postexercise egress of NK-cells. The blunted exercise response in CMVpos individuals was associated with a decreased relative redeployment of the CD158a+ and CD57+ NK-cell subsets in younger and older individuals. In addition, we show that aging is associated with a CMV-independent increase in the proportion of NK-cells expressing the terminal differentiation marker CD57, while CMV is associated with an age-dependent decrease in the proportion of NK-cells expressing the inhibitory receptors KLRG1 (in the younger group) and CD158a (in the older group). Collectively, these data suggest that CMV may decrease NK-cell mediated immunosurveillance after exercise in both younger and older individuals. |
| doi_str_mv | 10.1155/2015/979645 |
| format | Article |
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We showed previously that CMV seropositivity impairs the redeployment of NK-cells with exercise in the young. In the current study, we examined the effect of aging on the redeployment of NK-cells with exercise in the context of CMV. We show here that CMV blunts the exercise-induced redeployment of NK-cells in both younger (23–39 yrs) and older (50–64 yrs) subjects with older CMVneg subjects showing the largest postexercise mobilization and 1 h postexercise egress of NK-cells. The blunted exercise response in CMVpos individuals was associated with a decreased relative redeployment of the CD158a+ and CD57+ NK-cell subsets in younger and older individuals. In addition, we show that aging is associated with a CMV-independent increase in the proportion of NK-cells expressing the terminal differentiation marker CD57, while CMV is associated with an age-dependent decrease in the proportion of NK-cells expressing the inhibitory receptors KLRG1 (in the younger group) and CD158a (in the older group). Collectively, these data suggest that CMV may decrease NK-cell mediated immunosurveillance after exercise in both younger and older individuals.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2015/979645</identifier><identifier>PMID: 26583066</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Age ; Aging ; Analysis ; CD57 Antigens - metabolism ; Cytomegalovirus ; Cytomegalovirus infections ; Cytomegalovirus Infections - metabolism ; Cytomegalovirus Infections - pathology ; Exercise ; Flow Cytometry ; Genetic aspects ; Genotype & phenotype ; Health aspects ; Humans ; Infections ; Killer cells ; Killer Cells, Natural - cytology ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Laboratories ; Lymphocytes ; Male ; Middle Aged ; Oxygen Consumption ; Phenotype ; Physiological aspects ; Receptors, KIR2DL1 - metabolism ; Stress response ; Studies ; Young Adult</subject><ispartof>Oxidative medicine and cellular longevity, 2015-01, Vol.2015 (2015), p.1-10</ispartof><rights>Copyright © 2015 Austin B. Bigley et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Austin B. Bigley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Austin B. Bigley et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-bb72e9b7a146dcc7e13ec4df42b968522014171867f0f2f6f39afc7835df9ba53</citedby><cites>FETCH-LOGICAL-c495t-bb72e9b7a146dcc7e13ec4df42b968522014171867f0f2f6f39afc7835df9ba53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637106/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637106/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26583066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Davison, Gareth</contributor><creatorcontrib>Simpson, Richard J.</creatorcontrib><creatorcontrib>Agha, Nadia</creatorcontrib><creatorcontrib>Spielmann, Guillaume</creatorcontrib><creatorcontrib>Bigley, Austin B.</creatorcontrib><title>The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in Man</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>The redeployment of NK-cells in response to an acute bout of exercise is thought to be an integral component of the “fight-or-flight” response, preparing the body for potential injury or infection. We showed previously that CMV seropositivity impairs the redeployment of NK-cells with exercise in the young. In the current study, we examined the effect of aging on the redeployment of NK-cells with exercise in the context of CMV. We show here that CMV blunts the exercise-induced redeployment of NK-cells in both younger (23–39 yrs) and older (50–64 yrs) subjects with older CMVneg subjects showing the largest postexercise mobilization and 1 h postexercise egress of NK-cells. The blunted exercise response in CMVpos individuals was associated with a decreased relative redeployment of the CD158a+ and CD57+ NK-cell subsets in younger and older individuals. In addition, we show that aging is associated with a CMV-independent increase in the proportion of NK-cells expressing the terminal differentiation marker CD57, while CMV is associated with an age-dependent decrease in the proportion of NK-cells expressing the inhibitory receptors KLRG1 (in the younger group) and CD158a (in the older group). Collectively, these data suggest that CMV may decrease NK-cell mediated immunosurveillance after exercise in both younger and older individuals.</description><subject>Adult</subject><subject>Age</subject><subject>Aging</subject><subject>Analysis</subject><subject>CD57 Antigens - metabolism</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus infections</subject><subject>Cytomegalovirus Infections - metabolism</subject><subject>Cytomegalovirus Infections - pathology</subject><subject>Exercise</subject><subject>Flow Cytometry</subject><subject>Genetic aspects</subject><subject>Genotype & phenotype</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infections</subject><subject>Killer cells</subject><subject>Killer Cells, Natural - cytology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Laboratories</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen Consumption</subject><subject>Phenotype</subject><subject>Physiological aspects</subject><subject>Receptors, KIR2DL1 - metabolism</subject><subject>Stress response</subject><subject>Studies</subject><subject>Young Adult</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkd2LEzEUxYMo7lp98l0CvogybjKTj-ZFKKWri_UDWZ9DJnPTZpkmdTJTt_-9GWatq0_ChQTyy7n33IPQc0reUsr5RUkov1BSCcYfoHOqWFkQpdjD052QM_QkpRtCRFUy-hidlYLPKyLEOYrXW8Ar58D2CUeHFxvAJjR4bXoIPV4e-7iDjWnjwXdDwldhJH0MONfnj8US2hZ_3UKI_XE__VzdQmd9AvwN0j6G5A8QICXsA_5kwlP0yJk2wbO7c4a-X66ulx-K9Zf3V8vFurBM8b6oa1mCqqWhTDTWSqAVWNY4VtZKzHmZPTMq6VxIR1zphKuUcVbOK944VRtezdC7SXc_1DtobDbTmVbvO78z3VFH4_XfL8Fv9SYeNBOVpHlRM_TqTqCLPwZIvd75ZLNdEyAOSVNZcUV4xcdeL_9Bb-LQhWxvpHJJQckfKm8TtA8u5r52FNULxlkpCSej1puJsl1MqQN3GpkSPcatx7j1FHemX9x3eWJ_55uB1xOw9aExP_3_qUFGwJl7sBz1ql9GL7sZ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Simpson, Richard J.</creator><creator>Agha, Nadia</creator><creator>Spielmann, Guillaume</creator><creator>Bigley, Austin B.</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in Man</title><author>Simpson, Richard J. ; 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We showed previously that CMV seropositivity impairs the redeployment of NK-cells with exercise in the young. In the current study, we examined the effect of aging on the redeployment of NK-cells with exercise in the context of CMV. We show here that CMV blunts the exercise-induced redeployment of NK-cells in both younger (23–39 yrs) and older (50–64 yrs) subjects with older CMVneg subjects showing the largest postexercise mobilization and 1 h postexercise egress of NK-cells. The blunted exercise response in CMVpos individuals was associated with a decreased relative redeployment of the CD158a+ and CD57+ NK-cell subsets in younger and older individuals. In addition, we show that aging is associated with a CMV-independent increase in the proportion of NK-cells expressing the terminal differentiation marker CD57, while CMV is associated with an age-dependent decrease in the proportion of NK-cells expressing the inhibitory receptors KLRG1 (in the younger group) and CD158a (in the older group). Collectively, these data suggest that CMV may decrease NK-cell mediated immunosurveillance after exercise in both younger and older individuals.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>26583066</pmid><doi>10.1155/2015/979645</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aging Analysis CD57 Antigens - metabolism Cytomegalovirus Cytomegalovirus infections Cytomegalovirus Infections - metabolism Cytomegalovirus Infections - pathology Exercise Flow Cytometry Genetic aspects Genotype & phenotype Health aspects Humans Infections Killer cells Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Laboratories Lymphocytes Male Middle Aged Oxygen Consumption Phenotype Physiological aspects Receptors, KIR2DL1 - metabolism Stress response Studies Young Adult |
| title | The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in Man |
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