T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome
Humans have coevolved with a complex community of bacterial species also referred to as the microbiome, which reciprocally provides critical contributions to human metabolism and immune system development. Gut microbiome composition differs significantly between individuals depending on host genetic...
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| Veröffentlicht in: | BioMed research international 2015-01, Vol.2015 (2015), p.1-9 |
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| description | Humans have coevolved with a complex community of bacterial species also referred to as the microbiome, which reciprocally provides critical contributions to human metabolism and immune system development. Gut microbiome composition differs significantly between individuals depending on host genetics, diet, and environmental factors. A dysregulation of the symbiotic nature of the intestinal host-microbial relationship and an aberrant and persistent immune response are the fundamental processes involved in inflammatory bowel diseases (IBD). Considering the essential role of T cells in IBD and the contributing role of the microbiome in shaping the immune response during the pathogenesis of IBD, this review focuses on the complex relationship, interplay, and communication between the gut microbiome and T cells, including their differentiation into different subsets of effector or regulatory cells. |
| doi_str_mv | 10.1155/2015/504638 |
| format | Article |
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R. ; Ghishan, F. K. ; Shehab, K. W. ; Larmonier, C. B.</creator><contributor>Chikovani, Tinatin</contributor><creatorcontrib>Kiela, P. R. ; Ghishan, F. K. ; Shehab, K. W. ; Larmonier, C. B. ; Chikovani, Tinatin</creatorcontrib><description>Humans have coevolved with a complex community of bacterial species also referred to as the microbiome, which reciprocally provides critical contributions to human metabolism and immune system development. Gut microbiome composition differs significantly between individuals depending on host genetics, diet, and environmental factors. A dysregulation of the symbiotic nature of the intestinal host-microbial relationship and an aberrant and persistent immune response are the fundamental processes involved in inflammatory bowel diseases (IBD). Considering the essential role of T cells in IBD and the contributing role of the microbiome in shaping the immune response during the pathogenesis of IBD, this review focuses on the complex relationship, interplay, and communication between the gut microbiome and T cells, including their differentiation into different subsets of effector or regulatory cells.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/504638</identifier><identifier>PMID: 26583115</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Antigens ; Biomedical research ; Gastrointestinal Microbiome - immunology ; Health aspects ; Homeostasis ; Humans ; Immune system ; Immune Tolerance ; Inflammation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - immunology ; Inflammatory Bowel Diseases - microbiology ; Inflammatory Bowel Diseases - pathology ; Intestinal Mucosa - immunology ; Intestinal Mucosa - microbiology ; Lymphocytes ; Metabolites ; Mortality ; Pathogenesis ; Physiological aspects ; Review ; Small intestine ; Studies ; Symbiosis ; T cell receptors ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - microbiology ; T-Lymphocytes - immunology ; T-Lymphocytes - microbiology ; T-Lymphocytes - pathology</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-9</ispartof><rights>Copyright © 2015 C. B. Larmonier et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 C. B. Larmonier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 C. B. 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| subjects | Antigens Biomedical research Gastrointestinal Microbiome - immunology Health aspects Homeostasis Humans Immune system Immune Tolerance Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - microbiology Inflammatory Bowel Diseases - pathology Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Lymphocytes Metabolites Mortality Pathogenesis Physiological aspects Review Small intestine Studies Symbiosis T cell receptors T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - microbiology T-Lymphocytes - immunology T-Lymphocytes - microbiology T-Lymphocytes - pathology |
| title | T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome |
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