Role of Exosomal Noncoding RNAs in Lung Carcinogenesis
Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cance...
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| Veröffentlicht in: | BioMed research international 2015-01, Vol.2015 (2015), p.1-10 |
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| description | Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology. |
| doi_str_mv | 10.1155/2015/125807 |
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Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/125807</identifier><identifier>PMID: 26583084</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Apoptosis ; Biomarkers ; Carcinogenesis - genetics ; Cell growth ; Chinese medicine ; Communication ; Development and progression ; Exosomes - genetics ; Gene expression ; Gene Expression Regulation, Neoplastic ; Health aspects ; Humans ; Lung cancer ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Medical prognosis ; Medical research ; Metastasis ; MicroRNAs - biosynthesis ; MicroRNAs - genetics ; Physiological aspects ; Proteins ; Review ; RNA ; RNA, Untranslated - biosynthesis ; RNA, Untranslated - genetics ; Roles ; Thoracic surgery ; Tumors</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-10</ispartof><rights>Copyright © 2015 Tao Sun et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Tao Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Tao Sun et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-a8ba7113a0acf21aeb92ec2a5830e001f62c02ee513858d01ddfd2cf561cb50f3</citedby><cites>FETCH-LOGICAL-c528t-a8ba7113a0acf21aeb92ec2a5830e001f62c02ee513858d01ddfd2cf561cb50f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637011/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637011/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26583084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Corbeil, Denis</contributor><creatorcontrib>Xia, Shi-Jin</creatorcontrib><creatorcontrib>Lv, Guoying</creatorcontrib><creatorcontrib>Kalionis, Bill</creatorcontrib><creatorcontrib>Sun, Tao</creatorcontrib><creatorcontrib>Gao, Wen</creatorcontrib><title>Role of Exosomal Noncoding RNAs in Lung Carcinogenesis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology.</description><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Carcinogenesis - genetics</subject><subject>Cell growth</subject><subject>Chinese medicine</subject><subject>Communication</subject><subject>Development and progression</subject><subject>Exosomes - genetics</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Metastasis</subject><subject>MicroRNAs - biosynthesis</subject><subject>MicroRNAs - genetics</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Review</subject><subject>RNA</subject><subject>RNA, Untranslated - biosynthesis</subject><subject>RNA, Untranslated - genetics</subject><subject>Roles</subject><subject>Thoracic surgery</subject><subject>Tumors</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkd1LHDEUxYNUqmx96rsM9KUoW3OTyce-FJZF28KiIO1zyGZu1shsYic7fvz3ZlzdWp8MgeSSH-fk3kPIZ6DfAIQ4YRTECTChqdoh-4xDPZZQw4ftnfM9cpDzNS1Lg6QT-ZHsMSk0p7reJ_IytVglX53ep5xWtq3OU3SpCXFZXZ5PcxViNe9LMbOdCzEtMWIO-RPZ9bbNePB8jsifs9Pfs5_j-cWPX7PpfOwE0-ux1QurALil1nkGFhcTho7ZwR0pBS-ZowxRANdCNxSaxjfMeSHBLQT1fES-b3Rv-sUKG4dx3dnW3HRhZbsHk2ww_7_EcGWW6dbUkitanEfk67NAl_72mNdmFbLDtrURU58NqFpqpZhU70C5mNBaCVrQL2_Q69R3sUxioMqWAsQ_amlbNCH6VL7oBlEzrcUQBjzZHm8o16WcO_Tb7oCaIWMzZGw2GRf68PVAtuxLogU42gBXITb2LrxPDQuC3r6CRc0U8EcVrrSe</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Xia, Shi-Jin</creator><creator>Lv, Guoying</creator><creator>Kalionis, Bill</creator><creator>Sun, Tao</creator><creator>Gao, Wen</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Role of Exosomal Noncoding RNAs in Lung Carcinogenesis</title><author>Xia, Shi-Jin ; Lv, Guoying ; Kalionis, Bill ; Sun, Tao ; Gao, Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-a8ba7113a0acf21aeb92ec2a5830e001f62c02ee513858d01ddfd2cf561cb50f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Carcinogenesis - 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| subjects | Apoptosis Biomarkers Carcinogenesis - genetics Cell growth Chinese medicine Communication Development and progression Exosomes - genetics Gene expression Gene Expression Regulation, Neoplastic Health aspects Humans Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Medical prognosis Medical research Metastasis MicroRNAs - biosynthesis MicroRNAs - genetics Physiological aspects Proteins Review RNA RNA, Untranslated - biosynthesis RNA, Untranslated - genetics Roles Thoracic surgery Tumors |
| title | Role of Exosomal Noncoding RNAs in Lung Carcinogenesis |
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