Prevention of Abdominal Aortic Aneurysm Progression by Targeted Inhibition of Matrix Metalloproteinase Activity With Batimastat-Loaded Nanoparticles

RATIONALE:Matrix metalloproteinases (MMPs)–mediated extracellular matrix destruction is the major cause of development and progression of abdominal aortic aneurysms. Systemic treatments of MMP inhibitors have shown effectiveness in animal models, but it did not translate to clinical success either b...

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Veröffentlicht in:	Circulation research 2015-11, Vol.117 (11), p.e80-e89
Hauptverfasser:	Nosoudi, Nasim, Nahar-Gohad, Pranjal, Sinha, Aditi, Chowdhury, Aniqa, Gerard, Patrick, Carsten, Christopher G, Gray, Bruce H, Vyavahare, Naren R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Abdominal - drug effects Aorta, Abdominal - enzymology Aorta, Abdominal - immunology Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - chemically induced Aortic Aneurysm, Abdominal - drug therapy Aortic Aneurysm, Abdominal - enzymology Aortic Aneurysm, Abdominal - immunology Aortic Aneurysm, Abdominal - pathology Calcium Chloride Chemistry, Pharmaceutical Disease Models, Animal Disease Progression Drug Carriers Elastin - immunology Elastin - metabolism Immunoconjugates - administration & dosage Immunoconjugates - chemistry Immunoconjugates - metabolism Macrophages - drug effects Macrophages - enzymology Male Matrix Metalloproteinase Inhibitors - administration & dosage Matrix Metalloproteinase Inhibitors - chemistry Matrix Metalloproteinase Inhibitors - metabolism Matrix Metalloproteinases - metabolism Mice Nanoparticles Phenylalanine - administration & dosage Phenylalanine - analogs & derivatives Phenylalanine - chemistry Phenylalanine - metabolism Polyesters - chemistry Proteolysis Rats, Sprague-Dawley RAW 264.7 Cells Thiophenes - administration & dosage Thiophenes - chemistry Thiophenes - metabolism Time Factors Vascular Calcification - enzymology Vascular Calcification - pathology Vascular Calcification - prevention & control
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