Cold agglutinin disease ; a laboratory challenge

Cold agglutinin disease ; a laboratory challenge

Introduction: Autoimmune haemolytic anemia (AIHA) is a complex process characterized by an immune reaction against red blood cell self-antigens. The analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. This paper...

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Veröffentlicht in:Iranian red crescent medical journal 2015-10, Vol.17 (10), p.1-3
Hauptverfasser: Nikousefat, Zahra, Javdani, Musa, Hashemnia, Muhammad, Jalili, Ali, Haratyan, Abbas
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Sprache:eng
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Blood
Case Report
Cold agglutinin syndrome
Diseases
Hemolytic anemia, Autoimmune
الأمراض
الدم
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container_issue 10
container_start_page 1
container_title Iranian red crescent medical journal
container_volume 17
creator Nikousefat, Zahra
Javdani, Musa
Hashemnia, Muhammad
Jalili, Ali
Haratyan, Abbas
description Introduction: Autoimmune haemolytic anemia (AIHA) is a complex process characterized by an immune reaction against red blood cell self-antigens. The analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. This paper was written to alert technologists and pathologists to the presence of cold agglutinins and its effect on laboratory tests. Case Presentation: A 72-year-old female presented to the Shafa laboratory for hematology profile evaluation. CBC indices showed invalid findings with the Sysmex automated hematology analyzer. Checking the laboratory process showed precipitation residue sticking to the sides of the tube. After warming the tubes, results become valid and the problem attributed to cold agglutinin disease. In this situation, aggregation of RBCs, which occurs at t < 30°C, causes invalid findings meanwhile working with automated hematology analyzer. Conclusions: Knowledge of this phenomenon can help prevent wasting too much time and make an early and accurate diagnosis.
doi_str_mv 10.5812/ircmj.18954
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The analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. This paper was written to alert technologists and pathologists to the presence of cold agglutinins and its effect on laboratory tests. Case Presentation: A 72-year-old female presented to the Shafa laboratory for hematology profile evaluation. CBC indices showed invalid findings with the Sysmex automated hematology analyzer. Checking the laboratory process showed precipitation residue sticking to the sides of the tube. After warming the tubes, results become valid and the problem attributed to cold agglutinin disease. In this situation, aggregation of RBCs, which occurs at t &lt; 30°C, causes invalid findings meanwhile working with automated hematology analyzer. 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subjects Blood
Case Report
Cold agglutinin syndrome
Diseases
Hemolytic anemia, Autoimmune
الأمراض
الدم
title Cold agglutinin disease ; a laboratory challenge
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