Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification

Foldback priming at DNA double-stranded breaks is one mechanism proposed to initiate palindromic gene amplification, a common feature of cancer cells. Here, we show that small (5–9 bp) inverted repeats drive the formation of large palindromic duplications, the major class of chromosomal rearrangemen...

Ausführliche Beschreibung