Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown

Chromosomal instability (CIN) is a hallmark of solid tumor biology and is implicated in carcinogenesis. Preferentially eliminating malignant cells by targeting CIN and aneuploidy is an attractive antineoplastic strategy. We previously reported that CDK2 antagonism causes lung cancer cells to undergo...

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Veröffentlicht in:	Molecular cancer therapeutics 2015-11, Vol.14 (11), p.2576-2585
Hauptverfasser:	Hu, Shanhu, Lu, Yun, Orr, Bernardo, Godek, Kristina, Mustachio, Lisa Maria, Kawakami, Masanori, Sekula, David, Compton, Duane A, Freemantle, Sarah, Dmitrovsky, Ethan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase - drug effects Anaphase - genetics Animals Binding Sites - genetics Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Centrosome - drug effects Centrosome - metabolism Cyclin-Dependent Kinase 2 - antagonists & inhibitors Cyclin-Dependent Kinase 2 - metabolism Cyclins - metabolism Humans Immunoblotting Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mutation Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Purines - pharmacology RNA Interference Serine - genetics Serine - metabolism Threonine - genetics Threonine - metabolism Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism
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