Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17

Solar ultraviolet irradiation is an environmental carcinogen that causes skin cancer. Caspase-7 is reportedly expressed at reduced levels in many cancers. The present study was designed to examine the role of caspase-7 in solar-simulated light (SSL)-induced skin cancer and to elucidate its underlyin...

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Veröffentlicht in:	Carcinogenesis (New York) 2015-11, Vol.36 (11), p.1372-1380
Hauptverfasser:	Lee, Mee-Hyun, Lim, Do Young, Kim, Myoung Ok, Lee, Sung-Young, Shin, Seung Ho, Kim, Jae Young, Kim, Sung-Hyun, Kim, Dong Joon, Jung, Sung Keun, Yao, Ke, Kundu, Joydeb Kumar, Lee, Hye Suk, Lee, Cheol-Jung, Dickinson, Sally E, Alberts, David, Bowden, G Timothy, Stratton, Steven, Curiel, Clara, Einspahr, Janine, Bode, Ann M, Surh, Young-Joon, Cho, Yong-Yeon, Dong, Zigang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Caspase 7 - genetics Caspase 7 - metabolism Cells, Cultured Epidermis - enzymology Epidermis - pathology Epidermis - radiation effects Female Gene Knockout Techniques Keratinocytes - enzymology Keratins - physiology Male Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Original Manuscript Proteolysis Radiation Injuries, Experimental - enzymology Skin Neoplasms - enzymology Skin Neoplasms - genetics Skin Neoplasms - pathology Sunlight - adverse effects Tumor Burden
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